Company News

Cosperpharm offers the complete series of intermediates for Nerandomilast (BI-1015550), covering key building blocks from the core heterocyclic scaffold to the cyclobutylmethanol side chain derivative, providing one-stop supply support for generic and innovative drug development.

Zavegepant (Zavzpret®) is a calcitonin gene-related peptide (CGRP) receptor antagonist approved for the acute treatment of migraine in adults. The synthesis of this complex pharmaceutical agent requires multiple key intermediates, each contributing specific structural elements to the final API.

Finerenone (BAY 94-8862, marketed as Kerendia®) is a first-in-class, non-steroidal mineralocorticoid receptor antagonist (MRA) developed by Bayer for the treatment of chronic kidney disease (CKD) associated with type 2 diabetes.

Osimertinib (AZD9291, marketed as Tagrisso®) is a third-generation, irreversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor developed by AstraZeneca for the treatment of non-small cell lung cancer (NSCLC) harboring EGFR T790M resistance mutations .

Tenapanor is the world's first intestinal sodium/hydrogen exchanger 3 (NHE3) inhibitor, and also the first intestinal phosphorus absorption inhibitor, with outstanding phosphorus-lowering efficacy and convenient administration. When used in combination with phosphorus binders, it can synergistically enhance the phosphorus-lowering benefit, while greatly reducing the number of daily pills taken by patients and the total volume of medications, significantly alleviating the burden of long-term medication.

Arbidol (umifenovir) is a broad-spectrum antiviral drug licensed for the treatment of influenza A and B in Russia since 2003 and in China since 2006, with a non-nucleoside membrane fusion inhibition mechanism that prevents the interaction of the influenza virus with the host cell. The synthesis of this API requires a sequence of precisely controlled steps, with Arbidol Hydrochloride being obtained through a six-step route: Nenitzescu reaction, acylation for phenolic hydroxyl protection, bromination, thiophenolisation, Mannich reaction, and final hydrochloride salt formation.