4-Isothiocyanato-2-(trifluoromethyl)benzonitrile (CAS 143782-23-4) is the key electrophilic building block that supplies the isothiocyanate sulfur and the 4-cyano-3-(trifluoromethyl)phenyl group for thiohydantoin ring formation. 4-Bromo-2-fluoro-N-methylbenzamide (CAS 749927-69-3) serves as the aniline branch precursor, providing the 3-fluoro-4-(methylcarbamoyl)phenyl pharmacophore through Ullmann-type coupling. N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine (CAS 1289942-66-0) and its methyl ester (CAS 1332524-01-2) are the coupled aniline intermediates bearing the 2-methylalanine linker that becomes the quaternary carbon of the thiohydantoin ring. Methyl 2-fluoro-4-[(1-methoxy-2-methyl-1-oxopropan-2-yl)amino]benzoate (CAS 1802242-47-2) is an alternative ester-protected aniline intermediate. The remaining building blocks—2-aminoisobutyric acid (CAS 62-57-7) and methyl 4-bromo-2-fluorobenzoate (CAS 179232-29-2)—serve as the upstream starting materials for the aniline branch.
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恩杂鲁胺 |
Enzalutamide |
915087-33-1 |
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4-Bromo-2-fluoro-N-methylbenzamide |
749927-69-3 |
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N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine |
1289942-66-0 |
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N-[3-Fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine methyl ester |
1332524-01-2 |
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4-isothiocyanato-2-(trifluoroMethyl)benzonitrile |
143782-23-4 |
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Methyl 2-fluoro-4-((1-methoxy-2-methyl-1-oxopropan-2-yl)amino)benzoate |
1802242-47-2 |
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2-Aminoisobutyric acid |
62-57-7 |
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Methyl 4-bromo-2-fluorobenzoate |
179232-29-2 |
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Each batch of Enzalutamide intermediates undergoes release testing including HPLC purity verification (≥98%), appearance assessment, and identity confirmation by spectroscopic methods. Batch-specific Certificates of Analysis accompany every shipment. Retention samples are maintained for traceability. Custom quality agreements, stability data, and additional documentation packages are available upon request for customers requiring enhanced regulatory support for their Enzalutamide manufacturing or analytical programs.
If you require any of these eight Enzalutamide intermediates for your manufacturing campaign, impurity profiling program, or process development work, please contact us. Cosperpharm supplies 4-isothiocyanato-2-(trifluoromethyl)benzonitrile, 4-bromo-2-fluoro-N-methylbenzamide, N-[3-fluoro-4-[(methylamino)carbonyl]phenyl]-2-methylalanine, its methyl ester, methyl 2-fluoro-4-[(1-methoxy-2-methyl-1-oxopropan-2-yl)amino]benzoate, 2-aminoisobutyric acid, and methyl 4-bromo-2-fluorobenzoate with the analytical rigor and documentation your Enzalutamide project demands. Reach out today to discuss quantities, lead times, and technical support.
