3-Quinuclidinone Hydrochloride

3-Quinuclidinone Hydrochloride is a pivotal pharmaceutical intermediate and certified reference standard in the industrial synthesis of several clinically approved drugs, most notably the muscarinic M₃ receptor antagonist solifenacin succinate (Vesicare®), a first‑line treatment for overactive bladder syndrome, as well as the muscarinic agonist cevimeline (Evoxac®) for xerostomia and Sjögren‘s syndrome, and the 5‑HT₃ receptor antagonist azasetron hydrochloride for chemotherapy‑induced nausea and vomiting. The ketone functionality of 3-Quinuclidinone Hydrochloride serves as the substrate for stereoselective enzymatic or chemical reduction to produce (R)-3-quinuclidinol, the essential chiral pharmacophore in solifenacin, with documented yield of 94–100% and enantiomeric excess exceeding 99.9%. In quality control contexts, 3-Quinuclidinone Hydrochloride is officially designated as Solifenacin Impurity 31 and Impurity 40, and as 3-Quinuclidinone (free base) is recognized as Solifenacin Related Compound 22. This makes 3-Quinuclidinone Hydrochloride an indispensable analytical reference standard for impurity profiling, analytical method development, forced degradation studies, quality control (QC) testing, and Abbreviated New Drug Application (ANDA) filings for generic solifenacin manufacturers. The rigid bicyclic scaffold of 3-Quinuclidinone Hydrochloride also serves as a versatile building block in the synthesis of novel CB1 and CB2 cannabinoid receptor ligands, mutant p53 reactivators for cancer research, and anticholinergic agents targeting Parkinson‘s disease and other movement disorders, demonstrating the exceptional therapeutic versatility of this conformationally locked quinuclidine framework.

Product Parameters

Quality Assurance at Cosperpharm

Each batch undergoes:

● Gas chromatography (GC) – purity ≥97.0%

● Non‑aqueous titration – purity ≥97.0%

● Refractive index – confirmatory analysis

● ¹H NMR – structural verification

● Appearance – colorless to light yellow to light orange clear liquid

A comprehensive COA, MSDS (with full GHS information), and certificate of origin accompany every shipment.

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Storage Conditions

Store 3-Quinuclidinone Hydrochloride in a tightly sealed container under inert atmosphere (nitrogen or argon) at –20 °C for long‑term storage or at 2–8 °C for short‑term storage. Keep the container dry, protected from light, and stored in a clean, well‑ventilated area away from strong oxidizing agents, strong bases, and sources of ignition. The crystalline solid is stable under recommended storage conditions. The compound is hygroscopic; therefore, desiccated storage is strongly recommended and the container should be opened only in a low‑humidity environment. Allow the sealed container to reach ambient temperature before opening to minimize moisture condensation.

Shelf life: 3 years when stored at –20 °C in a sealed container under inert atmosphere; 2 years when stored at 4 °C. Accelerated stability data (40 °C / 75% RH) and long‑term stability summaries are available upon request to support regulatory filings.

Handling precautions: Use only in a fume hood. Wear chemical‑resistant gloves (tested against EN 374 or equivalent), safety goggles, and a lab coat. Avoid generating dust or aerosols. Do not eat, drink or smoke in work areas. After handling, wash hands thoroughly. Contaminated clothing should be removed and washed before reuse. Refer to the Safety Data Sheet (SDS) for complete safety information.

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Securing 3-Quinuclidinone Hydrochloride for your solifenacin manufacturing campaign, impurity profiling program, or medicinal chemistry research should be straightforward. Cosperpharm makes it simple.