Cisplatin is a platinum-based chemotherapy agent widely used in the treatment of various carcinomas and sarcomas . Cisplatin exhibits its anticancer effect via DNA cross-linkage, leading to cell growth arrest and consequent apoptosis . Cisplatin is believed to primarily bind cellular DNA, resulting in DNA-platinum adducts that prevent replication until damage is repaired . Cisplatin is supplied as a crystalline solid and is available as both an API for pharmaceutical manufacturing and as an analytical reference standard. The compound is insoluble in water but is formulated for intravenous administration .
|
Parameter |
Specification |
|
Product Name |
Cisplatin |
|
CAS Number |
15663-27-1 |
|
Molecular Formula |
Cl₂H₆N₂Pt |
|
Molecular Weight |
300.05 g/mol |
|
Appearance |
Yellow crystalline powder |
|
Water Solubility |
|
|
Storage Condition |
2–8 °C, protected from light |
The Founding Platinum Antineoplastic Agent
Cisplatin is the first-generation platinum drug that established the entire class of platinum-based chemotherapy agents . Its discovery revolutionized cancer treatment and remains a cornerstone of modern oncology.
Potent DNA Crosslinking Activity
Cisplatin forms 1,2-intrastrand crosslinks between adjacent guanine residues, distorting the DNA helix and blocking replication and transcription . This mechanism is highly effective against rapidly dividing cancer cells.
Broad Spectrum of Antitumor Activity
Cisplatin is active against testicular, ovarian, bladder, lung, head and neck, and other cancers. It is a component of curative regimens for testicular cancer.
Dual-Use: API and Reference Standard
Cosperpharm supplies Cisplatin at multiple quality levels: API grade for pharmaceutical manufacturing, and reference standard grade with full characterization.
Store Cisplatin at 2–8 °C in a tightly sealed container protected from light. Keep in a dry, well-ventilated area away from strong oxidizing agents.
Handling precautions: Cisplatin is classified with black box warnings including nephrotoxicity, peripheral neuropathy, severe nausea and vomiting, and myelosuppression . Use in a fume hood with appropriate PPE. Refer to the SDS for complete safety information.
Need Cisplatin for your oncology API manufacturing or analytical program? Contact Cosperpharm for pricing, documentation, or technical support.
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