Kopyrrol (CAS 55921-65-8), chemically known as pyrrolidinyl diaminopyrimidine oxide, is a water-soluble hair growth promoter structurally related to minoxidil. The molecule features a pyrimidine core bearing two amino groups and an N-oxide functionality at the 3-position, with a pyrrolidine ring attached at the 6-position.
Kopyrrol is a novel hair growth stimulant that functions as a potassium channel opener, similar in mechanism to minoxidil but with improved water solubility and safety profile. Kopyrrol works by improving blood circulation around hair follicles, delivering essential nutrients and oxygen to the hair root, thereby inhibiting hair loss and promoting hair regrowth. Kopyrrol also acts on the hair follicle cycle, transitioning follicles from the resting phase (telogen) to the growth phase (anagen) and prolonging the anagen phase. Studies have demonstrated that Kopyrrol can reduce serum 5α-reductase, androgen receptor, and dihydrotestosterone levels in animal models, contributing to its anti-hair loss efficacy.
Product Parameters
Parameter
Specification
Product Name
Kopyrrol
CAS Number
55921-65-8
Molecular Formula
C₈H₁₃N₅O
Molecular Weight
195.22 g/mol
Appearance
White to pale white crystalline powder
Melting Point
278 °C (dec.)
Boiling Point
549.3 ± 60.0 °C (predicted)
Density
1.60 g/cm³
pKa
4.89 ± 0.10 (predicted)
Storage Condition
2–8 °C, protected from light, sealed
Application
Structurally similar to minoxidil, it is an innovative and clinically proven 100% water-soluble, alcohol-free hair growth promoter.
By improving blood circulation on the skin surface, it provides the required nutrients and oxygen to the hair roots, thereby achieving the effects of inhibiting hair loss, strengthening hair roots, and promoting hair growth. By opening potassium ion channels, it transforms hair follicles from the telogen phase to the anagen phase, and can extend the anagen phase of hair.
Mechanism of action
1、It repairs weakened hair follicle cells by supplying the nutrients required for hair growth, and acts on the deep structure of the hair root, thereby increasing the number of hairs in the growth phase.
2、Acts on the hair roots, which play a vital role in maintaining a healthy scalp and beautiful hair, via blood circulation. It is often used in hair care products to combat hair loss caused by premature senescence of the hair roots.
Contact Us
For water-soluble hair growth actives and cosmetic formulation ingredients, Cosperpharm is your trusted partner. Contact our team today to discuss how Kopyrrol can enhance your anti-hair loss product line.
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