1,1'-Biphenyl, 3-bromo-2-methyl-

1,1'-Biphenyl, 3-bromo-2-methyl- is a key intermediate for the construction of more complex biphenyl‑containing molecules, including sartan antihypertensives, agrochemical fungicides, and advanced materials. The bromine atom of 1,1'-Biphenyl, 3-bromo-2-methyl- is ideally positioned for a subsequent Suzuki coupling to extend the molecular architecture with aryl, heteroaryl, or alkenyl groups. Because 1,1'-Biphenyl, 3-bromo-2-methyl- is a stable liquid, it can be precisely dispensed by syringe or pump in continuous‑flow reactors. Process chemists rely on 1,1'-Biphenyl, 3-bromo-2-methyl- to serve as a common late‑stage intermediate that can be divergently converted into multiple lead series through parallel coupling reactions.

Product Parameters

Product Advantages

1. Ready‑to‑Couple Aryl Bromide – Reacts readily under standard Suzuki, Negishi, or Buchwald conditions without pre‑activation.

2. Ortho‑Methyl Steric Control – The adjacent methyl group can be used to influence atropisomerism or restrict rotation in biaryl products.

3. Liquid at Room Temperature – Easy to transfer and measure, ideal for automated synthesis platforms and flow chemistry.

4. High Regioisomeric Purity – The 4‑bromo isomer is stringently controlled to avoid difficult separations downstream.

5. Full Documentation Package – Batch‑specific GC chromatograms, NMR spectra, and residual solvent reports are provided.

FAQ

Q1: Can this aryl bromide be used in lithiation reactions?

A: Yes, treatment with n‑BuLi at −78 °C in anhydrous THF generates the corresponding aryllithium, which can be quenched with various electrophiles.

Q2: What are typical Suzuki coupling conditions for this substrate?

A: 1.0 equiv of this bromide, 1.1 equiv of arylboronic acid, 2 mol% Pd(PPh₃)₄, Na₂CO₃ (2 M), DME, 85 °C, 12 h.

Quality Assurance at Cosperpharm

Each batch undergoes:

● Gas chromatography (GC) – purity ≥97.0%

● Non‑aqueous titration – purity ≥97.0%

● Refractive index – confirmatory analysis

● ¹H NMR – structural verification

● Appearance – colorless to light yellow to light orange clear liquid

A comprehensive COA, MSDS (with full GHS information), and certificate of origin accompany every shipment.

Contact Us

For a competitive quotation on this liquid bromobiphenyl intermediate, or to receive a small‑scale sample for method validation, contact Cosperpharm’s commercial operations team — we typically respond with full pricing and availability data within hours of your inquiry.