![1-[2,3-Bis[(9Z,12Z)-octadeca-9,12-dien-1-yloxy]propyl]pyrrolidine](/upload/8820/1-2-3-bis-9z-12z-octadeca-9-12-dien-1-yloxy-propyl-pyrrolidine-641184.webp "1-[2,3-Bis[(9Z,12Z)-octadeca-9,12-dien-1-yloxy]propyl]pyrrolidine")
1-[2,3-Bis[(9Z,12Z)-octadeca-9,12-dien-1-yloxy]propyl]pyrrolidine is a cationic lipid designed for RNA and vaccine delivery applications. A-066 (the synonym for 1-[2,3-Bis[(9Z,12Z)-octadeca-9,12-dien-1-yloxy]propyl]pyrrolidine) has been demonstrated to form LNPs encapsulating TetR siRNA, which induce significant antitumor efficacy in orthotopic hepatocellular carcinoma models.As an analog of DODMA, 1-[2,3-Bis[(9Z,12Z)-octadeca-9,12-dien-1-yloxy]propyl]pyrrolidine replaces the dimethylamino head group with a pyrrolidine ring, potentially modulating its pKa and endosomal escape efficiency for optimized nucleic acid payload release. 1-[2,3-Bis[(9Z,12Z)-octadeca-9,12-dien-1-yloxy]propyl]pyrrolidine is particularly valued in the development of LNP‑based formulations for mRNA vaccines, siRNA therapeutics, and gene editing platforms requiring efficient intracellular delivery of genetic cargo.
![1-[2,3-Bis[(9Z,12Z)-octadeca-9,12-dien-1-yloxy]propyl]pyrrolidine](/upload/8820/image/20260626/1--2-3-bis--9z-12z--octadeca-9-12-dien-1-yloxy-propyl-pyrrolidine2-526845.webp)
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Parameter |
Specification |
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Product Name |
1-[2,3-Bis[(9Z,12Z)-octadeca-9,12-dien-1-yloxy]propyl]pyrrolidine |
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CAS Number |
1192362-77-8 |
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Molecular Formula |
C₄₃H₇₉NO₂ |
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Molecular Weight |
642.09 g/mol |
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Purity (HPLC) |
≥95%–99% (depending on supplier and grade) |
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kPa |
9.58±0.20（Predicted） |
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Boiling Point |
674.9±55.0 °C(Predicted) |
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Density |
0.897±0.06 g/cm3(Predicted |
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Advantage |
Detail |
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Production Strength |
GMP-certified campus spanning 100+ mu, 3 multi-purpose workshops, 6 D-grade clean zone production lines, and 150+ reactors (20L–5000L), supporting high/low temp, anaerobic & hydrogenation; kg to ton scale production. |
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Fast Delivery |
R&D samples: one week; commercial orders: 1–2 months after payment. Express (DHL/FedEx) or air/sea freight available. |
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Global Partners |
Trusted by 30+ pharmaceutical companies in USA, Europe, India, Brazil, and Southeast Asia; long-term cooperation with generic drug manufacturers, CROs, and impurity standard distributors. |
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Licensed Exporter |
Valid drug import/export license — no compliance delays. |
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Dual Quality Grades |
Both research/pharma grade（≥98%）and high-purity impurity grade（≥99%）available to meet diverse customer needs. |
1. DODMA Analog with Pyrrolidine Head Group Optimization
1-[2,3-Bis[(9Z,12Z)-octadeca-9,12-dien-1-yloxy]propyl]pyrrolidine is a structural analog of DODMA (1,2-dioleyloxy-N,N-dimethyl-3-aminopropane) with the key modification of a pyrrolidine head group. This substitution alters the pKa of the ionizable amine and influences the lipid’s protonation behavior across endosomal pH gradients (pH 5.5–6.5), potentially enhancing endosomal escape efficiency — a critical step for effective cytosolic delivery of nucleic acid payloads.
2. Proven Efficacy in siRNA Delivery and Antitumor Models
LNPs formulated with 1-[2,3-Bis[(9Z,12Z)-octadeca-9,12-dien-1-yloxy]propyl]pyrrolidine encapsulating TetR siRNA demonstrated significant antitumor efficacy in orthotopic hepatocellular carcinoma models, validating its utility as a functional ionizable lipid for in vivo gene silencing applications.
3. Versatile for RNA and Vaccine Delivery Platforms
1-[2,3-Bis[(9Z,12Z)-octadeca-9,12-dien-1-yloxy]propyl]pyrrolidine forms Cationic-Based Lipid Encapsulation Systems (CaBLES) or Lipid‑Based Particles suitable for delivering a wide range of anionic substrates — from small interfering RNA to larger mRNA constructs — positioning it as a versatile tool for gene therapy, vaccine development, and CRISPR‑based genome editing research.
4. Ether-Linked Tails for Enhanced Chemical Stability
The ether linkages between the glycerol backbone and the two linoleyl chains provide greater hydrolytic stability compared to ester-linked lipids, offering advantages for long‑term formulation storage without compromising the fusogenic properties conferred by the two cis‑double bonds in each tail.
5. High Purity Grades with Full Analytical Characterization
Cosperpharm supplies 1-[2,3-Bis[(9Z,12Z)-octadeca-9,12-dien-1-yloxy]propyl]pyrrolidine at ≥95% HPLC purity, with each batch accompanied by ¹H NMR identity confirmation and purity data. Higher purity grades (≥99%) are available upon request for customers requiring maximal consistency for GLP or GMP‑grade research.
Q1: What are the primary applications of this lipid?
A: 1-[2,3-Bis[(9Z,12Z)-octadeca-9,12-dien-1-yloxy]propyl]pyrrolidine is used in RNA and vaccine delivery, particularly in LNP formulations for siRNA, mRNA, and other nucleic acid therapeutics. It has shown efficacy in hepatocellular carcinoma models.
Q2: What is the lead time for this product from Cosperpharm?
A: Lead times vary based on current inventory and synthesis requirements. Cosperpharm offers flexible sourcing with custom synthesis options available. Please contact our sales team for current lead time estimates.
Ready to advance your LNP formulation research with high‑purity 1-[2,3-Bis[(9Z,12Z)-octadeca-9,12-dien-1-yloxy]propyl]pyrrolidine? Cosperpharm is your partner in sourcing quality cationic lipids for nucleic acid delivery. Reach out to our team for pricing, availability, or technical support — we are here to help your research succeed.
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No. 2 Yangguang 3rd Road, Duodao Chemical Cycle Industrial Park, Jingmen City, Hubei Province, China
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