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Product Name |
CAS No. |
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DMT-2'-O-MOE-A(Bz)-CE-Phosphoramidite |
251647-53-7 |
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DMT-2'-O-MOE-G(iBu)-CE-Phosphoramidite |
251647-55-9 |
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5-Me-DMT-2'-O-MOE-C(Bz)-CE-Phosphoramidite |
163759-94-2 |
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5-Me-DMT-2'-O-MOE-U-CE-Phosphoramidite |
163878-63-5 |
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The 2'-O-Methoxyethyl (MOE) modification is a highly effective chemical strategy used to improve the drug-like properties of oligonucleotides. By introducing a methoxyethyl group at the 2' position of the ribose sugar, MOE-modified oligonucleotides exhibit significantly increased resistance to nuclease degradation and enhanced binding affinity to target RNA. This modification is particularly valuable in antisense and siRNA therapeutics, where stability and potency are critical. Furthermore, our 5-Methyl C and U variants offer additional structural benefits, often contributing to improved duplex stability and reduced immune stimulation. Cosperpharma’s MOE phosphoramidites are synthesized under strict anhydrous conditions to ensure the highest coupling efficiency and product purity.
Cosperpharma’s 2'-O-MOE Phosphoramidites are essential tools for a variety of advanced research and therapeutic applications:
Antisense Oligonucleotides (ASOs): Providing the necessary stability and affinity for effective gene silencing in both research and clinical settings.
siRNA Therapeutics: Enhancing the metabolic stability and duration of action for RNA interference-based drugs.
Aptamer Development: Improving the binding characteristics and serum stability of nucleic acid aptamers for diagnostic and therapeutic use.
Exon Skipping and Splice Modulation: Supporting the development of therapies for genetic disorders by facilitating precise pre-mRNA targeting.
Cosperpharma is dedicated to supporting your advanced therapeutic development with top-tier MOE phosphoramidites. To learn more about our products, request a detailed specification sheet, or discuss custom synthesis requirements, please reach out to our team. We look forward to providing you with a tailored quote and exceptional service for your next project.
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