2,5-DIHYDROXY-1,4-BENZENEDIACETIC ACID

2,5-Dihydroxy-1,4-benzenediacetic acid is a versatile organic compound widely used as an important intermediate in the synthesis of pharmaceuticals, dyes, and other organic compounds. The compound's dense functionality—two phenolic hydroxyl groups and two acetic acid moieties—provides multiple sites for chemical modification and metal coordination. 2,5-Dihydroxy-1,4-benzenediacetic acid exhibits strong chelating properties, allowing it to form stable complexes with metal ions for applications in analytical chemistry, biochemistry, and materials science. In biochemical research, 2,5-Dihydroxy-1,4-benzenediacetic acid has been used to investigate enzyme mechanisms, study the effects of drugs and dyes on biochemical and physiological processes, and examine protein structure and function. Additionally, 2,5-Dihydroxy-1,4-benzenediacetic acid serves as a monomer linker for metal-organic framework (MOF) synthesis and as a monomer for the synthesis of poly(p-phenylene vinylene) (PPV) polymers.

Product Parameters

Product Advantages

 Dense Multifunctionality for Diverse Applications

2,5-Dihydroxy-1,4-benzenediacetic acid features four oxygen-containing functional groups—two phenolic hydroxyls and two carboxylic acids—arranged symmetrically on a rigid benzene core. This dense array of coordinating and hydrogen-bonding functionalities makes it an exceptionally versatile building block for coordination chemistry, materials science, and organic synthesis.

 Exceptional Chelating and Metal-Coordinating Properties

The combination of phenolic hydroxyl and carboxylic acid groups enables 2,5-Dihydroxy-1,4-benzenediacetic acid to form stable complexes with metal ions. This chelating ability is valuable in analytical chemistry, biochemistry, environmental science, and the synthesis of metal-organic frameworks (MOFs).

 Versatile Reactivity in Organic Synthesis

2,5-Dihydroxy-1,4-benzenediacetic acid can act as both a nucleophile and an electrophile, making it a versatile participant in various enzymatic reactions and synthetic transformations. This dual reactivity expands the range of derivatives and applications accessible from this compound.

 Key Building Block for MOFs and PPV Polymers

2,5-Dihydroxy-1,4-benzenediacetic acid serves as a monomer linker for MOF synthesis and as a monomer for synthesizing PPVs (poly(p-phenylene vinylene)). These applications position the compound at the intersection of coordination chemistry and materials science.

 Proven Utility in Biochemical Research

2,5-Dihydroxy-1,4-benzenediacetic acid has been used to study enzyme mechanisms, investigate the effects of drugs and dyes on biochemical processes, and examine protein structure and function. Its role in laccase-mediated reactions with sulfonamides highlights its relevance in biocatalysis research.

Storage Conditions

Store 2,5-Dihydroxy-1,4-benzenediacetic acid in a tightly sealed container under inert atmosphere (argon) at 2–8 °C. Keep the container dry and protected from light. The compound should be stored in a clean, well-ventilated area away from strong oxidizing agents. Allow the sealed container to reach ambient temperature before opening to minimize moisture condensation.

Handling precautions: Use only in a fume hood. Wear chemical-resistant gloves, safety goggles, and a lab coat. Avoid generating dust or aerosols. Do not eat, drink or smoke in work areas. After handling, wash hands thoroughly. Refer to the Safety Data Sheet (SDS) for complete safety information.

Product Quality Assurance

Cosperpharm has established a comprehensive quality assurance system for 2,5-Dihydroxy-1,4-benzenediacetic acid that meets the rigorous expectations of pharmaceutical intermediate manufacturing, materials science, and biochemical research:

Thorough analytical characterization. Each batch undergoes multi-technique analytical release testing: HPLC purity (≥96.5%), titration (96.5%–103.5% with NaOH), appearance verification (white to off-white powder or crystals), and infrared spectroscopy for structural confirmation.

Full batch traceability with retention samples. From raw material procurement through synthesis, purification, drying, and final packaging, every step is fully documented and traceable. Each batch receives a unique lot number with sufficient retention samples maintained in accordance with Cosperpharm quality procedures.

Stability monitoring program. Cosperpharm conducts ongoing stability studies under recommended storage conditions (2–8 °C under argon). Stability summaries are available to support customer research and development documentation needs.

Documentation ready for research and development. Every shipment includes a Certificate of Analysis (COA) with batch-specific purity and characterization data, and customs documentation for international delivery. Custom quality documentation is available upon request.

Customer-initiated quality audits. Qualified customers are welcome to audit Cosperpharm's manufacturing, quality control, and documentation facilities. Please contact our regulatory team to schedule an audit.

Contact Us

From MOF synthesis and polymer development to pharmaceutical intermediate production and biochemical research, Cosperpharm is your trusted source for high-purity 2,5-Dihydroxy-1,4-benzenediacetic acid. Contact our team today to discuss your application requirements, request a quotation, or learn more about our quality assurance program.