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Product Name |
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DMTr-2'-O-TBDMS-L-A(Bz)-3'-CE-Phosphoramidite |
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DMTr-2'-O-TBDMS-L-G(iBu)-3'-CE-Phosphoramidite |
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DMTr-2'-O-TBDMS-L-C(Ac)-3'-CE-Phosphoramidite |
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DMTr-2'-O-TBDMS-L-U-3'-CE-Phosphoramidite |
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Unmatched Biostability: The most significant advantage of L-RNA is its complete resistance to degradation by natural nucleases. Because natural enzymes are highly stereospecific, they cannot recognize the L-enantiomer. Oligonucleotides synthesized with Cosperpharma’s L-RNA phosphoramidites exhibit exceptional stability in serum and other biological fluids, dramatically extending their half-life and therapeutic potential.
High Coupling Efficiency for Complex Synthesis: The synthesis of Spiegelmers requires monomers that perform flawlessly. Our L-RNA phosphoramidites are produced under strictly controlled anhydrous conditions and utilize the proven 2'-O-TBDMS protecting group strategy. This ensures high, reproducible coupling yields, allowing you to construct full-length L-RNA sequences with confidence.
Rigorous Quality Control: Every batch of our L-RNA monomers undergoes stringent HPLC purity verification and structural confirmation. We guarantee the stereochemical integrity of our L-enantiomers, ensuring your final product has the exact mirror-image conformation required for biological activity.
Comprehensive Documentation: We provide detailed Certificates of Analysis (COA) and Safety Data Sheets (SDS) with every shipment. Customized documentation packages are available to support your regulatory filings and quality assurance processes.
Cosperpharma’s L-RNA Phosphoramidites are essential tools for a variety of cutting-edge applications:
Spiegelmer Development: Creating nuclease-resistant aptamers that bind to target proteins with high affinity and specificity for therapeutic applications.
Diagnostics: Developing highly stable probes and biosensors that maintain integrity in complex biological matrices.
Antisense Therapeutics: Exploring mirror-image antisense oligonucleotides with extended in vivo half-lives.
Chemical Biology Research: Investigating the stereochemical basis of nucleic acid-protein interactions and enzyme recognition.
We are excited to support your pioneering work with mirror-image oligonucleotides. If you are exploring L-RNA for your next therapeutic or diagnostic project, our team is ready to assist. Contact Cosperpharma today to discuss your specific requirements, request a detailed specification sheet, or receive a customized quotation for your L-RNA synthesis needs.
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