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Product Name |
CAS No. |
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DMT-2'-O-TBDMS-A(Bz)-CE-Phosphoramidite |
104992-55-4 |
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DMT-2'-O-TBDMS-G(iBu)-CE-Phosphoramidite |
147201-04-5 |
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DMT-2'-O-TBDMS-C(Ac)-CE-Phosphoramidite |
121058-88-6 |
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DMT-2'-O-TBDMS-U-CE-Phosphoramidite |
118362-03-1 |
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The 2'-O-TBDMS protecting group remains one of the most widely utilized chemistries for RNA synthesis due to its excellent balance of stability and ease of removal. During the synthesis cycle, the bulky TBDMS group effectively prevents unwanted 2'-OH reactivity, ensuring correct phosphoramidite coupling. Following synthesis, the TBDMS group can be cleanly removed under mild conditions—typically using fluoride ions or triethylamine trihydrofluoride—without degrading the sensitive RNA backbone. Cosperpharma’s TBDMS phosphoramidites are synthesized under rigorously controlled anhydrous conditions to ensure they meet the stringent requirements of modern RNA therapeutics and research.
Optimized for High-Yield RNA Synthesis: Our 2'-O-TBDMS monomers exhibit excellent coupling efficiencies, which is essential for synthesizing longer RNA sequences where even minor truncations can significantly impact biological activity. The high purity of our monomers minimizes the formation of failure sequences and enhances the overall yield of full-length product.
Consistent and Reliable Performance: Every lot of Cosperpharma’s TBDMS phosphoramidites is subjected to rigorous quality control, including HPLC purity analysis and structural confirmation. This batch-to-batch consistency ensures that your synthesis protocols deliver reproducible results, saving you valuable time and resources.
Comprehensive Support for RNA Therapeutics: As the demand for RNA-based medicines continues to grow, Cosperpharma is committed to providing the high-quality raw materials necessary for their development. Our TBDMS phosphoramidites are suitable for both small-scale research and large-scale manufacturing, supported by comprehensive documentation to aid in your regulatory submissions.
We understand that every synthesis project has unique requirements. Whether you need a small evaluation sample or a bulk quotation for commercial-scale production, our team is ready to assist. Contact Cosperpharma today to discuss your specific needs, request a detailed COA, or explore how our TBDMS phosphoramidites can accelerate your RNA research and development.
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