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Product Name |
CAS No. |
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DMT-2'-O-4'-C-Locked-A(Bz)-CE-Phosphoramidite |
206055-79-0 |
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DMT-2'-O-4'-C-Locked-G(iBu)-CE-Phosphoramidite |
N/A |
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DMT-2'-O-4'-C-Locked-G(dmf)-CE-Phosphoramidite |
N/A |
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DMT-2'-O-4'-C-Locked-5-Me-C(Bz)-CE-Phosphoramidite |
206055-82-5 |
|
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DMT-2'-O-4'-C-Locked-T-CE-Phosphoramidite |
206055-75-6 |
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Unmatched Thermal Stability and Affinity: The locked conformation of our LNA phosphoramidites significantly increases the melting temperature (Tm) of resulting duplexes. This allows for the design of shorter probes and primers with higher specificity, reducing background noise in hybridization assays and enhancing the potency of antisense therapeutics.
Exceptional Mismatch Discrimination: Because of the rigid sugar structure, LNA-modified oligonucleotides exhibit superior discrimination against single-nucleotide mismatches. This makes our monomers the ideal choice for demanding applications such as SNP genotyping and allele-specific PCR.
Versatile Protecting Group Options: To accommodate diverse synthetic and deprotection strategies, we offer our Locked-G monomers with both standard isobutyryl (iBu) and dimethylformamidine (dmf) protecting groups. The dmf variant is particularly advantageous for reducing deprotection time and minimizing side reactions under mild conditions.
High Purity for Sensitive Applications: Every lot of Cosperpharma’s LNA phosphoramidites undergoes rigorous HPLC purification and structural verification to ensure the highest possible coupling efficiency and product fidelity, even when incorporating multiple LNA monomers into a single sequence.
To maintain the integrity and performance of our 2'-O-4'-C-Locked Phosphoramidites, proper storage is essential. These products should be stored desiccated at -20°C, protected from light and moisture. Under these recommended conditions, the compounds are stable for up to 12 months. Before opening, allow vials to equilibrate to room temperature to prevent condensation. Once dissolved in anhydrous acetonitrile, solutions should be used promptly or stored under an inert gas atmosphere to prevent degradation.
We are eager to learn more about your specific oligonucleotide projects and how our Locked Phosphoramidites can contribute to your success. Whether you require a small sample for evaluation, a detailed COA, or a bulk quotation, our dedicated team is ready to provide exceptional support. Please get in touch with Cosperpharma today to discuss your requirements and let us help you achieve your research and development goals.
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