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3'-DMT-2'-OMe-A(Bz)-CE Reverse Phosphoramidite |
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3'-DMT-2'-OMe-G(iBu)-CE Reverse Phosphoramidite |
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3'-DMT-2'-OMe-C(Ac)-CE Reverse Phosphoramidite |
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3'-DMT-2'-OMe-U-CE Reverse Phosphoramidite |
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Engineered for Exonuclease Resistance: The primary advantage of reverse phosphoramidites lies in their ability to create inverted terminal linkages. By synthesizing oligonucleotides with 3'-3' or 5'-5' linkages at the termini, researchers can effectively block exonuclease degradation. This "capping" strategy significantly extends the serum half-life of therapeutic oligonucleotides, a critical factor for successful in vivo applications.
Combined Benefits of 2'-OMe Modification: These monomers incorporate the 2'-O-Methyl modification, which is renowned for enhancing binding affinity and providing additional nuclease resistance. The combination of the reverse orientation and 2'-OMe chemistry offers a powerful dual approach to stabilizing oligonucleotide therapeutics.
High Purity and Reliable Coupling: Cosperpharma’s reverse phosphoramidites are synthesized under rigorously controlled anhydrous conditions. Each lot undergoes stringent HPLC purification and structural confirmation to ensure high coupling efficiency and product fidelity, even when incorporating multiple reverse linkages into a single sequence.
Comprehensive Documentation: Every shipment is accompanied by a detailed Certificate of Analysis (COA) and Safety Data Sheet (SDS). Customized documentation packages are available to support your regulatory filings and quality assurance processes.
Applications
Cosperpharma’s 2'-OMe-Reverse Phosphoramidites are essential tools for a variety of advanced oligonucleotide applications:
Antisense Oligonucleotides (ASOs): Enhancing metabolic stability and extending the therapeutic window through terminal capping strategies.
siRNA Therapeutics: Improving the durability and potency of RNA interference-based drugs by protecting against exonuclease degradation.
Aptamer Development: Increasing the serum stability of nucleic acid aptamers for diagnostic and therapeutic applications.
Diagnostic Probes: Enhancing the stability of probes used in challenging biological matrices where nuclease activity is a concern.
We understand that stabilizing your oligonucleotide therapeutics is a critical step in your development process. If you are interested in evaluating our 2'-OMe-Reverse Phosphoramidites or would like to discuss how our reverse orientation chemistry can benefit your specific project, we invite you to connect with our technical team. Contact Cosperpharma today to request a detailed specification sheet, obtain a sample for evaluation, or receive a customized quotation.
