Product List
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Product Name |
CAS No. |
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DMT-2'-OMe-N1-methyl-Pseudouridine-CE-Phosphoramidite |
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N1-methyl-pseudouridine (m1Ψ) is a naturally occurring modified nucleoside that has become a cornerstone of successful mRNA therapeutic design. Unlike standard uridine, m1Ψ features a methyl group at the N1 position and a carbon-carbon glycosidic bond, which confers unique structural and biological properties. When incorporated into mRNA, this modification dramatically reduces activation of innate immune sensors such as TLR7 and TLR8, while simultaneously enhancing ribosome loading and protein translation. Cosperpharma’s DMT-2'-OMe-N1-methyl-Pseudouridine-CE-Phosphoramidite is synthesized under rigorously controlled anhydrous conditions to ensure the highest coupling efficiency and is specifically designed to meet the stringent purity requirements of mRNA vaccine and therapeutic production.
Cosperpharma’s Pseudouridine Phosphoramidite is an essential tool for a wide range of advanced RNA applications:
mRNA Vaccines and Therapeutics: Enabling the production of highly translatable, low-immunogenicity mRNA constructs for vaccines against infectious diseases and therapeutic proteins.
Protein Replacement Therapy: Supporting the development of mRNA-based treatments for genetic disorders by maximizing protein expression and minimizing immune activation.
Gene Editing: Enhancing the performance of CRISPR-Cas9 systems by improving the stability and translational efficiency of guide RNAs and repair templates.
Basic RNA Biology Research: Facilitating studies on RNA structure, stability, and immune recognition mechanisms.
We are committed to supporting your mRNA research and development with the highest quality modified nucleosides. If you are interested in evaluating our Pseudouridine Phosphoramidite or would like to discuss your specific synthesis requirements, we invite you to connect with our team. Contact Cosperpharma today to request a sample, obtain a detailed specification sheet, or receive a customized quotation.
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