1-Chloro-2-(chloroMethyl)-3,5-dioxahexane

1-Chloro-2-(chloromethyl)-3,5-dioxahexane (CAS 70905-45-2) is a multi‑functional, chlorine‑containing organic compound valued as a synthetic building block. At room temperature, it presents as a clear, colorless to almost colorless liquid with a characteristic ether‑like odor. The molecular formula is C₅H₁₀Cl₂O₂, with a molecular weight of 173.03 g/mol. [7†L12-L13][9†L23-L24] The compound is commercially available at purities exceeding 95.0% (GC), with higher grade material available for specialized applications.

1-Chloro-2-(chloromethyl)-3,5-dioxahexane is distinguished by its unique combination of functional groups: two acid-sensitive methoxy groups protect the central carbon as an acetal, and three halogens act as leaving groups. The central –OCH₂O– linkage is an acetal, which can be selectively cleaved under mild acidic conditions to reveal a reactive α‑chloro alcohol. The primary chloromethyl groups readily participate in nucleophilic substitution reactions (SN2) with a wide range of nucleophiles, including amines, thiols, and alkoxides. In the pharmaceutical industry, 1-chloro-2-(chloromethyl)-3,5-dioxahexane is employed as a key synthetic building block and intermediate for the manufacture of active pharmaceutical ingredients (APIs) such as ganciclovir and octreotide acetate, as its multi‑halogenated structure is crucial for constructing the side chains of complex antiviral and peptide drugs. Its excellent solubility profile allows it to serve as a specialized solvent for various organic and inorganic compounds, dissolving a broad spectrum of substances for use as a reaction medium in organic synthesis. Additionally, its rigid backbone and terminal leaving groups make it a suitable monomer for synthesizing specialty polymers, where it introduces specific chlorinated side chains to modify material properties.  The compound also serves as a precursor for generating unstable reactive intermediates, such as 2-(chloromethyl)-3,5-dioxa-1-hexene, which are used in further synthetic transformations.

Product Parameters

Precautionary Statements

● Avoid breathing dust/fume/gas/mist/vapours/spray

● Wash thoroughly after handling

● Use only outdoors or in a well‑ventilated area

● Wear protective gloves/protective clothing/eye protection/face protection

● IF ON SKIN: Wash with plenty of water

● IF INHALED: Remove person to fresh air and keep comfortable for breathing

● IF IN EYES: Rinse cautiously with water for several minutes; remove contact lenses if present and easy to do; continue rinsing

● Call a POISON CENTER/doctor if you feel unwell

● If skin irritation occurs: Get medical advice/attention

● Take off contaminated clothing and wash before reuse

● Store in a well‑ventilated place; keep container tightly closed

● Store locked up

● Dispose of contents/container in accordance with local regulations

Why Cosperpharm? – Our Competitive Advantages

Quality Assurance at Cosperpharm

Each batch undergoes:

● Gas chromatography (GC) – purity ≥97.0%

● Non‑aqueous titration – purity ≥97.0%

● Refractive index – confirmatory analysis

● ¹H NMR – structural verification

● Appearance – colorless to light yellow to light orange clear liquid

A comprehensive COA, MSDS (with full GHS information), and certificate of origin accompany every shipment.

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