2-[(3-Methylbenzyl)oxy]benzaldehyde (C₁₅H₁₄O₂, MW 226.27 g/mol) is an aromatic aldehyde featuring a benzaldehyde core connected via an ether linkage to a 3-methylbenzyl (meta-methylbenzyl) substituent. Structurally, the molecule comprises a salicylaldehyde-derived aromatic ring substituted at the ortho position with a 3-methylbenzyloxy (–O–CH₂–C₆H₄–CH₃) group. The presence of both an electrophilic aldehyde carbonyl and an electron-donating ether oxygen creates a polarized electronic environment that enables diverse chemical transformations. The meta‑methyl group on the pendant benzyl ring introduces additional steric and electronic modulation, making 2-[(3-Methylbenzyl)oxy]benzaldehyde a finely tuned synthetic building block for medicinal chemistry and organic synthesis research. The molecular scaffold is recognized in the literature for its role as a molecular probe targeting glutamine transporter proteins, a property that positions 2-[(3-Methylbenzyl)oxy]benzaldehyde at the interface of chemical synthesis and cancer biology research.
2-[(3-Methylbenzyl)oxy]benzaldehyde is a versatile organic intermediate employed across organic synthesis, medicinal chemistry, and chemical biology research. In medicinal chemistry, 2-[(3-Methylbenzyl)oxy]benzaldehyde has been identified as a molecular probe for studying glutamine transporter proteins, with documented activity in inhibiting tumor growth and cancer cell proliferation by blocking cellular uptake of glutamine — an essential amino acid for rapidly proliferating cancer cells. The aldehyde functionality of 2-[(3-Methylbenzyl)oxy]benzaldehyde enables further derivatization through oxidation to the corresponding carboxylic acid, reduction to the benzyl alcohol, or condensation with amines and other nucleophiles to produce Schiff bases and other adducts. Within organic synthesis workflows, 2-[(3-Methylbenzyl)oxy]benzaldehyde serves as a structural precursor for constructing more complex molecular architectures in drug discovery programs, particularly those targeting metabolic pathways in oncology research.
Product Parameters
Parameter
Specification
Product Name
2-[(3-Methylbenzyl)oxy]benzaldehyde
CAS Number
351984-86-6
Molecular Formula
C₁₅H₁₄O₂
Molecular Weight
226.27 g/mol
Purity (GC/HPLC)
≥95.0% — ≥98.0%
Physical Form
Liquid / Oil
Appearance
Colorless to pale yellow liquid
Boiling Point
373.2 °C at 760 mmHg
Density
1.10–1.12 g/cm³ (estimated)
Flash Point
148.8–168.7 °C
Storage Condition
Cool, dry place; store long-term in sealed container
HS Code
2912.49
Why Cosperpharm?
1. For researchers and process chemists requiring 2-[(3-Methylbenzyl)oxy]benzaldehyde for glutamine transporter studies or organic synthesis campaigns, Cosperpharm delivers consistently high‑purity material with the supply flexibility your project demands.
2. Authenticated sourcing with full traceability. Each batch of 2-[(3-Methylbenzyl)oxy]benzaldehyde is accompanied by a Certificate of Analysis (COA) documenting GC/HPLC purity (≥95% or higher, batch‑specific), identity confirmation, and appearance verification. We maintain batch‑specific retention samples and complete supply chain documentation.
3. R&D‑friendly packaging at competitive pricing. Whether you need 1g for exploratory screening or 100g for scale‑up studies, Cosperpharm offers flexible packaging options at prices that respect your research budget. R&D samples are typically available for shipment within 5–7 business days.
4. Technical support for downstream applications. Our team understands the chemistry of aromatic aldehydes and can provide guidance on oxidation, reduction, and condensation reactions involving 2-[(3-Methylbenzyl)oxy]benzaldehyde. Let us help you move from building block to bioactive molecule.
5. Transparent, reliable global delivery. Cosperpharm ships to research institutions, CROs, and pharmaceutical companies worldwide with full customs documentation included. We communicate lead times upfront — no hidden fees, no unexpected delays.
Product Advantages
1. Validated Molecular Probe for Glutamine Transporter Studies
2-[(3-Methylbenzyl)oxy]benzaldehyde has been characterized as a molecular probe for studying glutamine transporter proteins. Published literature indicates that compounds with this scaffold inhibit cellular glutamine uptake, thereby suppressing tumor growth and cancer cell proliferation — a feature of significant interest in oncology drug discovery.
2. Dual‑Functionality Scaffold
The combination of an aldehyde group (electrophilic, redox‑active, condensable with amines) and an ortho‑positioned ether linkage in 2-[(3-Methylbenzyl)oxy]benzaldehyde creates a versatile platform for divergent chemical synthesis. The aldehyde can be oxidized to the carboxylic acid, reduced to the benzyl alcohol, or converted to imines, hydrazones, and other derivatives — enabling rapid library generation for SAR studies.
3. High Purity for Reproducible Research
Cosperpharm supplies 2-[(3-Methylbenzyl)oxy]benzaldehyde at ≥95% purity, ensuring batch‑to‑batch consistency for sensitive biological assays and multi‑step synthetic sequences. Full characterization data are provided with every shipment.
4. Readily Handled Liquid Form
Unlike many solid intermediates, 2-[(3-Methylbenzyl)oxy]benzaldehyde is supplied as a liquid (pale yellow to colorless), simplifying precise volumetric dispensing and reaction setup in organic synthesis workflows.
Storage Conditions
Store 2-[(3-Methylbenzyl)oxy]benzaldehyde in a tightly sealed container in a cool, dry, well‑ventilated area. Protect from light and moisture. For long‑term storage (>6 months), storage at 2–8°C under inert atmosphere (nitrogen or argon) is recommended. The compound is stable under recommended storage conditions. Avoid exposure to strong oxidizing agents, strong bases, and sources of ignition.
Shelf life: 2 years when stored under recommended conditions.
Handling precautions: Use only in a fume hood. Wear chemical‑resistant gloves, safety goggles, and a lab coat. Avoid generating mists or aerosols. After handling, wash hands thoroughly. Refer to the Safety Data Sheet (SDS) for complete safety information.
Contact Us
Questions about 2-[(3-Methylbenzyl)oxy]benzaldehyde? Need a custom quantity or purity grade for your research program? Reach out to Cosperpharm today. Our team is ready to provide technical support, pricing, and delivery timelines.
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