2-(4-BENZYLOXYPHENYL)ETHANOL

2-(4-BENZYLOXYPHENYL)ETHANOL is a crystalline protected form of tyrosol (4‑hydroxyphenethyl alcohol) that is extensively used in the synthesis of pharmaceuticals, natural products, and functional materials. The free hydroxyl of 2-(4-BENZYLOXYPHENYL)ETHANOL can be smoothly converted to a mesylate or bromide to alkylate amines, thiols, or carbon nucleophiles, while the benzyl group remains stable to bases, mild acids, and oxidants. Medicinal chemists utilize 2-(4-BENZYLOXYPHENYL)ETHANOL as a latent phenol precursor in the preparation of β‑adrenergic receptor ligands, antiviral agents, and kinase inhibitors, where a para‑oxygenated aromatic ring is required but must be kept masked during early steps. Because 2-(4-BENZYLOXYPHENYL)ETHANOL is a well‑crystallized solid, it can be weighed precisely on the benchtop and stored for extended periods without the discoloration or viscosity increase typical of unprotected phenolic alcohols.

Product Parameters

Why Cosperpharm?

Cosperpharm manufactures 2-(4-BENZYLOXYPHENYL)ETHANOL with a focus on low residual benzyl halide levels — a critical quality parameter when this intermediate is used in amination reactions where benzyl chloride could generate unwanted N‑benzylated by‑products. Our process distills or crystallizes the product to remove excess benzyl bromide and the unreacted tyrosol, delivering a product that is ≥98% pure by GC with a clean, single‑peak chromatogram. We offer the flexibility to supply this building block in research‑scale glass bottles, kilo‑lab HDPE containers, or vacuum‑sealed foil bags for bulk orders, each accompanied by a batch‑specific CoA and SDS. For customers integrating this alcohol into a GMP sequence, we can provide residual solvent analysis and advice on the hydrogenolysis debenzylation endpoint.

Product Advantages

1.Protected Phenol, Activated Alcohol – The benzyl group shields the phenol while the alcohol remains free for selective oxidation, acylation, or alkylation.

2.Crystalline Solid – The compound is a non‑hygroscopic powder that is easy to handle, weigh, and store under ambient conditions.

3.Dual Functional Handles – The molecule can be elaborated at both ends: the alcohol provides a linker, and the benzyl group ultimately delivers a phenol.

4.Tyrosol Surrogate – Functions as a stable, protected equivalent of tyrosol in multistep syntheses where the free phenol would interfere.

5.Readily Available at Scale – Cosperpharm supplies from 25 g to 25 kg, ensuring continuity from medicinal chemistry to pilot production.

Storage Conditions

Store 2-(4-BENZYLOXYPHENYL)ETHANOL in a tightly sealed container, protected from moisture, at 2–8 °C. Under these conditions, the crystalline powder remains chemically stable and free‑flowing for at least 24 months. Avoid prolonged exposure to air to prevent minor oxidative yellowing.

Contact Us

To request a sample or discuss how this protected phenethyl alcohol can simplify your current synthetic sequence, reach out to Cosperpharm’s product specialist team — we can share representative HPLC chromatograms and a quote tailored to your project scale.