2,5-dichloroquinoline

2,5-dichloroquinoline itself is a privileged scaffold present in numerous bioactive molecules, including antimalarials (chloroquine, mefloquine), antibacterials (fluoroquinolones), and anticancer agents. The introduction of chlorine atoms in 2,5-Dichloroquinoline enhances metabolic stability and lipophilicity while offering orthogonal sites for diversification. 2,5-Dichloroquinoline is typically obtained as an off-white to pale yellow solid (melting point 76–77 °C) and is stable when stored under inert atmosphere at 2–8 °C. Its predicted pKa of –0.77±0.50 reflects the basicity of the quinoline nitrogen, which is significantly reduced by the electron-withdrawing chlorines, a property that makes 2,5-Dichloroquinoline particularly useful for designing metabolically stable drug candidates.

Product Parameters (2,5-Dichloroquinoline, CAS 59412-12-3)

Why Choose Cosperpharm for 2,5-dichloroquinoline?

● Reaction‑ready quality – Our 2,5‑dichloroquinoline is produced via a validated two‑step route (oxidation of 5‑chloroquinoline followed by chlorination with POCl₃), ensuring low residual metals and consistent substitution pattern.

● Scalable for your timeline – From 10 g for a screening library to 100 kg for a pilot campaign – we adapt to your phase.

● Strict inert storage – Each batch is packed under argon to prevent moisture pick‑up and shipped with a desiccant.

● Full traceability – Every delivery includes a CoA with HPLC purity, and we can provide NMR/MS data on request.

● Regulatory ready – As a licensed exporter, we support your DMF, IND, or ANDA filings with appropriate documentation.

Typical Preparation Route (for reference)

2,5-Dichloroquinoline is commonly prepared from 5‑chloroquinoline via N‑oxidation followed by chlorination:

Step 1: 5‑Chloroquinoline (30 g, 183 mmol) is treated with m‑CPBA (39 g, 192 mmol) in DCM at 15 °C for 12 h, quenched with Na₂SO₃ solution, and extracted. The crude product is purified by column chromatography to give the N‑oxide intermediate (yield ~49%).

Step 2: The N‑oxide (19 g, 106 mmol) is reacted with POCl₃ (32 g, 212 mmol) in DCM at 40 °C for 1.5 h. After aqueous work‑up and purification, 2,5‑dichloroquinoline is obtained as a white solid (yield ~40%).

This route is reliable and can be scaled up under controlled conditions.

Storage & Handling Recommendations

● Storage: Keep under inert atmosphere (nitrogen or argon) at 2–8 °C in a tightly sealed container. Avoid exposure to air, moisture, and strong oxidants.

● Stability: Stable for at least 24 months when stored as recommended.

● Handling: Use in a fume hood with standard PPE (gloves, goggles, lab coat). The compound may be an irritant – avoid inhalation and skin contact.

Contact us

Interested in 2,5-Dichloroquinoline (CAS 59412‑12‑3)? We make it easy to get started.

● Request a sample – small quantities shipped within a week.

● Ask for a quote – competitive pricing, any volume.

● Custom documentation – CoA, MSDS, NMR, or special packaging.

● Technical discussion – our chemists can help with application advice.

Simply email or call us – tell us what you need, and we’ll take care of the rest. Cosperpharm is here to be your long‑term, reliable partner for 2,5‑dichloroquinoline and other heterocyclic intermediates.