2-Hydroxy-4-(methoxycarbonyl)benzoic acid

2-Hydroxy-4-(methoxycarbonyl)benzoic acid (CAS 29602-00-4) is a multi-functional organic building block combining both a free carboxylic acid and a methyl ester on the same aromatic ring, with an ortho-positioned hydroxyl group. This specific substitution pattern positions 2-Hydroxy-4-(methoxycarbonyl)benzoic acid as a valuable intermediate for constructing polyesters, coordination polymers, and pharmaceutical compounds.

In biochemical contexts, 2-Hydroxy-4-(methoxycarbonyl)benzoic acid interacts with key enzymes like heme oxygenase (HO1) and myeloperoxidase (MPO), which are central to oxidative stress and inflammatory responses. Studies demonstrate that 2-Hydroxy-4-(methoxycarbonyl)benzoic acid can attenuate carbon tetrachloride-induced liver damage by reducing serum transaminases, hepatic lipid peroxidation, and collagen content.

In materials science, 2-Hydroxy-4-(methoxycarbonyl)benzoic acid serves as a monomer for bio-based polyesters and as a ligand in constructing Metal-Organic Frameworks (MOFs), leveraging its rigid aromatic core and dual carboxylate groups to form stable coordination polymers.

Product Parameters

Frequently Asked Questions (FAQ)

Q1: What is the primary application of this compound?

A: It is used as a building block in organic synthesis (polyesters, MOFs), biochemical research (oxidative stress and inflammation studies), and medicinal chemistry (hepatoprotective agent development).

Q2: What purity does Cosperpharm provide?

A: Cosperpharm provides this product with ≥98% purity by HPLC as standard. Higher purity grades are available upon request.

Q3: What biological activities have been reported?

A: The compound has shown hepatoprotective effects in animal models, reducing liver damage induced by carbon tetrachloride (CCl₄). It also interacts with heme oxygenase (HO1) and myeloperoxidase (MPO).

Storage Conditions

● Temperature: 2–8°C (refrigerated); store under nitrogen

● Container: Airtight, tightly sealed

● Protection: Store away from moisture, light, and strong oxidizing agents

● Desiccation: Keep in a desiccated environment; the compound may be hygroscopic

● Shelf life: 24 months when stored as recommended

● Incompatibilities: Strong oxidizing agents, strong bases, and strong acids

Safety Notice: The compound is harmful if swallowed, in contact with skin, or if inhaled. Use appropriate PPE, avoid generating dust, and ensure adequate ventilation. Wear protective gloves, protective clothing, and eye/face protection. Do not breathe dust/fume/gas/mist/vapours/spray. If swallowed, call a POISON CENTER/doctor immediately.

Quality Assurance at Cosperpharm

Each batch undergoes:

● Gas chromatography (GC) – purity ≥97.0%

● Non‑aqueous titration – purity ≥97.0%

● Refractive index – confirmatory analysis

● ¹H NMR – structural verification

● Appearance – colorless to light yellow to light orange clear liquid

A comprehensive COA, MSDS (with full GHS information), and certificate of origin accompany every shipment.

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