2-Propenoic Acid, 2‑(Decyldithio)ethyl Ester (CAS 1624618‑09‑2) is a specialized acrylate monomer and cationic lipid precursor used in advanced drug delivery systems. 2-Propenoic Acid, 2‑(Decyldithio)ethyl Ester is specifically designed for the preparation of liposomes for siRNA delivery, where its reducible disulfide bond enables triggered release of the oligonucleotide payload upon cellular uptake. Additionally, 2-Propenoic Acid, 2‑(Decyldithio)ethyl Ester is employed in the formulation of lipid nanoparticles for oral plasmid DNA delivery, where facile surface modification improves mucus permeability and delivery efficiency of the nanoparticles. Moreover, 2-Propenoic Acid, 2‑(Decyldithio)ethyl Ester serves as a versatile building block for synthesizing bioreducible polymers, with documented transfection efficiency improvements in vitro compared to non‑cleavable alternatives. With a molecular weight of 304.51 g/mol and supplied as a colorless to light‑yellow liquid, 2-Propenoic Acid, 2‑(Decyldithio)ethyl Ester is the preferred choice for researchers developing next‑generation nucleic acid delivery vehicles.
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Parameter |
Specification |
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Product Name |
2-Propenoic Acid, 2-(Decyldithio)ethyl Ester |
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CAS Number |
1624618-09-2 |
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Molecular Formula |
C₁₅H₂₈O₂S₂ |
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Molecular Weight |
304.51 g/mol |
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Purity |
≥98% |
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Advantage |
Detail |
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Production Strength |
GMP-certified campus spanning 100+ mu, 3 multi-purpose workshops, 6 D-grade clean zone production lines, and 150+ reactors (20L–5000L), supporting high/low temp, anaerobic & hydrogenation; kg to ton scale production. |
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Fast Delivery |
R&D samples: one week; commercial orders: 1–2 months after payment. Express (DHL/FedEx) or air/sea freight available. |
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Global Partners |
Trusted by 30+ pharmaceutical companies in USA, Europe, India, Brazil, and Southeast Asia; long-term cooperation with generic drug manufacturers, CROs, and impurity standard distributors. |
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Licensed Exporter |
Valid drug import/export license — no compliance delays. |
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Dual Quality Grades |
Both research/pharma grade（≥98%）and high-purity impurity grade（≥99%）available to meet diverse customer needs. |
2-Propenoic Acid, 2‑(Decyldithio)ethyl Ester can be synthesized through the esterification of acrylic acid with 2‑(decyldithio)ethanol:
Step 1 — Preparation of 2‑(decyldithio)ethanol: Decyl mercaptan (C₁₀H₂₁SH) is oxidized in the presence of 2‑mercaptoethanol (HS‑CH₂CH₂OH) to form the mixed disulfide 2‑(decyldithio)ethanol.
Step 2 — Esterification: The resulting 2‑(decyldithio)ethanol is esterified with acrylic acid in the presence of a coupling agent such as DCC or EDC, or via acid‑catalyzed Fischer esterification, to yield 2-Propenoic Acid, 2‑(Decyldithio)ethyl Ester.
Step 3 — Purification: The crude product is purified by column chromatography or distillation to achieve ≥98% puryit.
Each batch undergoes:
● Gas chromatography (GC) – purity ≥97.0%
● Non‑aqueous titration – purity ≥97.0%
● Refractive index – confirmatory analysis
● ¹H NMR – structural verification
● Appearance – colorless to light yellow to light orange clear liquid
A comprehensive COA, MSDS (with full GHS information), and certificate of origin accompany every shipment.
Interested in incorporating 2-Propenoic Acid, 2‑(Decyldithio)ethyl Ester into your next LNP formulation or bioreducible polymer development project? Reach out to Cosperpharm today for a quote, specification sheet, or to discuss custom synthesis options. Our dedicated customer support team is ready to assist you with product inquiries, documentation requests, and shipment coordination. Whether you’re a biotech startup scaling up from bench to pilot or an established pharmaceutical company requiring kilogram quantities, we’re here to help you succeed.
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