5-(Dimethylamino)pentylamine is a valuable building block in medicinal chemistry and material science for introducing a basic, solubilizing tail onto pharmacophores. The primary amine of 5-(Dimethylamino)pentylamine can be acylated, sulfonylated, or coupled to carboxylic acids with complete selectivity over the tertiary dimethylamino group, which remains protonated at physiological pH. In drug discovery, 5-(Dimethylamino)pentylamine is employed to prepare peripherally selective opioid antagonists, cationic antimicrobial peptides, and ion‑channel blockers where a fixed positive charge improves target engagement. The industrial availability of 5-(Dimethylamino)pentylamine as a colorless liquid in multi‑kilogram quantities makes it an economical choice for process chemistry scale‑up.
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Parameter |
Specification |
|
Product Name |
5-(Dimethylamino)pentylamine |
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CAS Number |
3209-46-9 |
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Molecular Formula |
C₇H₁₈N₂ |
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Molecular Weight |
130.23 g/mol |
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Appearance |
Colorless to pale yellow liquid |
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Boiling Point |
50℃/ 3mm |
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Density |
0.83–0.84 g/cm³ at 20 °C |
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Purity (GC) |
≥98.0% |
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Solubility |
Miscible with water, ethanol, THF; forms monohydrochloride salt soluble in water |
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Storage Condition |
2-8°C, protect from light |
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Shelf Life |
24 months under recommended conditions |
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Advantage |
Detail |
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Production Strength |
GMP-certified campus spanning 100+ mu, 3 multi-purpose workshops, 6 D-grade clean zone production lines, and 150+ reactors (20L–5000L), supporting high/low temp, anaerobic & hydrogenation; kg to ton scale production. |
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Fast Delivery |
R&D samples: one week; commercial orders: 1–2 months after payment. Express (DHL/FedEx) or air/sea freight available. |
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Global Partners |
Trusted by 30+ pharmaceutical companies in USA, Europe, India, Brazil, and Southeast Asia; long-term cooperation with generic drug manufacturers, CROs, and impurity standard distributors. |
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Licensed Exporter |
Valid drug import/export license — no compliance delays. |
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Dual Quality Grades |
Both research/pharma grade（≥98%）and high-purity impurity grade（≥99%）available to meet diverse customer needs. |
5-(Dimethylamino)pentylamine can be synthesized by the reductive amination of 5‑aminopentanal with dimethylamine, or more commonly by the reduction of 5‑(dimethylamino)pentanenitrile (CAS 3209-45-8) with hydrogen over Raney nickel or lithium aluminum hydride. The resulting crude diamine is purified by fractional distillation. Cosperpharm’s route ensures low residual nitrile and amide by‑products.
1.Opioid Antagonist Peripheral Restriction
Used to attach a permanently charged dimethylammonium tail to naloxone or naltrexone scaffolds.
2.Cationic Antimicrobial Peptide Synthesis
Serves as a lysine mimic with a dimethylamino terminus in solid‑phase peptide synthesis.
3.Ion‑Channel Blocker Design
Incorporated into voltage‑gated sodium channel blockers to introduce a basic amine that interacts with the selectivity filter.
4.Surfactant and Emulsifier Production
The primary amine is acylated with fatty acids to produce amidoamine surfactants for personal care.
5.Polyurethane Chain Extender
Reacts with diisocyanates to introduce tertiary amine sites into polyurethane foams.
To include this 5-(Dimethylamino)pentylamine in your next polymer or drug conjugate project, contact Cosperpharm’s amines product manager — we can dispatch a 100‑mL sample for your initial experiments and provide a formal quotation for larger volumes within 24 hours.
Address
No. 2 Yangguang 3rd Road, Duodao Chemical Cycle Industrial Park, Jingmen City, Hubei Province, China
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