6-CHLORO-7-METHYLCHROMONE

6-Chloro-7-methylchromone (CAS 67029-84-9) is a heterocyclic, substituted chromone (1,4‑benzopyrone) and a versatile building block broadly utilized in early‑stage drug discovery and agrochemical research. The molecular formula is C₁₀H₇ClO₂ with a molecular weight of 194.61 g/mol, and the compound is typically supplied as a white to off‑white crystalline powder or solid.

In pharmaceutical research, 6-chloro-7-methylchromone serves as a key intermediate in the synthesis of various pharmaceuticals, particularly those targeting inflammatory diseases and cancer; its unique structural features allow modifications that enhance therapeutic efficacy. The compound has also been investigated for its own biological properties: it exhibits inhibition of cyclooxygenase (COX) enzymes, a crucial target in inflammation pathways, and has shown promising antimicrobial activity, significantly inhibiting the growth of Vibrio parahaemolyticus in laboratory studies. Furthermore, 6-chloro-7-methylchromone derivatives have been evaluated as melanin‑concentrating hormone receptor 1 (MCHR1) antagonists, indicating potential for metabolic and obesity research.

In addition to its direct biological activities, 6-chloro-7-methylchromone is employed in the preparation of fluorescent probes for real‑time visualization of cellular processes, in the synthesis of natural products (particularly antioxidant flavonoids), in the development of agrochemicals (e.g., as plant growth regulators), and in materials science for the creation of novel polymers and coatings.

Product Parameters

Precautionary Statements:

● Avoid breathing dust/fume/gas/mist/vapours/spray

● Use only outdoors or in a well-ventilated area

● Wear protective gloves/protective clothing/eye protection/face protection

● Wash thoroughly after handling

● IF ON SKIN: Wash with plenty of water

● IF INHALED: Remove person to fresh air and keep comfortable for breathing

● IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing

● Call a POISON CENTER/doctor if you feel unwell

● Take off contaminated clothing and wash it before reuse

● Store in a well-ventilated place. Keep container tightly closed

● Store locked up

● Dispose of contents/container in accordance with local regulations

Storage Conditions

● Temperature: Store at room temperature (15–25 °C). For long‑term storage, keep in a cool, dry place.

● Atmosphere: Store under inert gas (argon or nitrogen) to prevent oxidation and moisture absorption.

● Container: Airtight, tightly sealed container

● Protection: Store away from moisture, light, and strong oxidizing agents

● Incompatibilities: Strong oxidizing agents, strong bases, strong acids

● Stability: Stable under recommended storage conditions for up to 24 months

● Shelf life: 2–3 years when stored as a solid; in‑solution storage should be in single‑use aliquots at –80 °C

● DOT/IATA Transport: Not hazardous material under normal transport conditions

Handling recommendation: As a crystalline powder, the compound is easy to handle. Use in a fume hood and avoid generating dust. The compound may cause skin and eye irritation; wear appropriate PPE (gloves, goggles, lab coat). After opening, purge the container with inert gas and reseal tightly. Safety data sheet (SDS) is available upon request.

Quality Assurance at Cosperpharm

Each batch undergoes:

● Gas chromatography (GC) – purity ≥97.0%

● Non‑aqueous titration – purity ≥97.0%

● Refractive index – confirmatory analysis

● ¹H NMR – structural verification

● Appearance – colorless to light yellow to light orange clear liquid

A comprehensive COA, MSDS (with full GHS information), and certificate of origin accompany every shipment.

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