Boc-β-(3-pyridyl)-Ala-OH

Boc-β-(3-pyridyl)-Ala-OH is a versatile unnatural amino acid building block widely used in peptide synthesis, medicinal chemistry, and drug discovery programs. As a Boc-protected amino acid, Boc-β-(3-pyridyl)-Ala-OH is compatible with Boc-based solid-phase peptide synthesis (SPPS) strategies, enabling the straightforward incorporation of the 3-pyridyl-alanine residue into peptide sequences. The 3-pyridyl side chain of Boc-β-(3-pyridyl)-Ala-OH provides a rigid, heteroaromatic moiety that can participate in π-π stacking interactions, hydrogen bonding, and electrostatic interactions with biological targets — making Boc-β-(3-pyridyl)-Ala-OH a valuable tool for structure-activity relationship (SAR) studies and the development of peptide-based therapeutics. The unnatural amino acid nature of Boc-β-(3-pyridyl)-Ala-OH also contributes to enhanced proteolytic stability compared to natural amino acid-containing peptides, a feature that is critical for the development of peptide drug candidates. Furthermore, Boc-β-(3-pyridyl)-Ala-OH serves as a key building block in the synthesis of pyridine-containing bioactive compounds, including enzyme inhibitors, receptor modulators, and antimicrobial agents.

 Product Parameters

Why Cosperpharm?

When your peptide synthesis or medicinal chemistry program requires unnatural amino acid building blocks like Boc-β-(3-pyridyl)-Ala-OH, Cosperpharm delivers with the quality, documentation, and supply reliability that pharmaceutical and biotech customers demand.

Quality you can trust. Boc-β-(3-pyridyl)-Ala-OH is a specialized unnatural amino acid that requires rigorous quality control to ensure optical purity and freedom from process-related impurities. Cosperpharm’s analytical release protocol includes HPLC purity verification (≥99.0% by TLC), optical rotation measurement for enantiomeric purity confirmation, melting point verification, and identity confirmation by ¹H NMR and MS.

Documentation that supports your research. Every shipment includes a Certificate of Analysis (COA) with batch-specific purity and characterization data. For customers integrating Boc-β-(3-pyridyl)-Ala-OH into drug development programs, Cosperpharm provides comprehensive documentation packages, stability summaries, and custom quality agreements upon request.

Flexible supply across all research stages. Cosperpharm supplies Boc-β-(3-pyridyl)-Ala-OH from 1g–50g quantities for research and SAR studies, to 100g–500g batches for process development, to kilogram-scale lots for commercial manufacturing. R&D samples ship within 5–7 business days; bulk orders ship within 2–3 weeks.

Technical support for peptide chemists. Our team can advise on coupling conditions, deprotection strategies, and compatibility with various peptide synthesis platforms — because we have extensive experience with this and other unnatural amino acid building blocks.

Global reach with transparent pricing. Cosperpharm ships to pharmaceutical manufacturers, CROs, and research laboratories worldwide, with full customs documentation included. Volume discounts apply at larger scales, and we communicate lead times upfront.

Product Advantages

 Unnatural Amino Acid for Enhanced Bioactivity

Boc-β-(3-pyridyl)-Ala-OH is a non-natural amino acid that introduces a rigid, heteroaromatic pyridine ring into peptide sequences. This unnatural amino acid can enhance binding affinity, selectivity, and metabolic stability compared to natural amino acid-containing peptides — making Boc-β-(3-pyridyl)-Ala-OH a valuable tool for medicinal chemistry and drug discovery.

 Pyridine Side Chain for Molecular Recognition

The 3-pyridyl side chain of Boc-β-(3-pyridyl)-Ala-OH provides a versatile pharmacophore capable of engaging in π-π stacking interactions, hydrogen bonding (via the pyridine nitrogen), and electrostatic interactions with biological targets. This makes Boc-β-(3-pyridyl)-Ala-OH particularly valuable for SAR studies and the development of receptor modulators and enzyme inhibitors.

 Boc Protection for Standard Peptide Synthesis

Boc-β-(3-pyridyl)-Ala-OH is fully compatible with Boc-based solid-phase peptide synthesis strategies, enabling the straightforward incorporation of the 3-pyridyl-alanine residue into peptide sequences. The Boc group is selectively removed under mild acidic conditions (e.g., TFA), allowing for controlled chain elongation.

 High Optical Purity for Reproducible Results

Boc-β-(3-pyridyl)-Ala-OH is supplied with verified enantiomeric purity, as confirmed by optical rotation measurement ([α]₂₀/D +15.5 ± 1°, c = 1% in ethanol). This ensures batch-to-batch reproducibility in peptide synthesis and biological studies.

 Crystalline Form for Convenient Handling

Boc-β-(3-pyridyl)-Ala-OH is supplied as a crystalline powder (white to off-white to pale yellow), making it convenient to weigh and handle. The crystalline form also contributes to enhanced long-term storage stability when stored at –20°C under recommended conditions.

Storage Conditions

Store Boc-β-(3-pyridyl)-Ala-OH in a tightly sealed container at –20°C. Keep the container dry, protected from light, and stored in a clean, well-ventilated area away from strong oxidizing agents, strong acids, and strong bases. The compound is stable under recommended storage conditions. Boc-β-(3-pyridyl)-Ala-OH is hygroscopic; therefore, desiccated storage is strongly recommended and the container should be opened only in a low-humidity environment. Allow the sealed container to reach ambient temperature before opening to minimize moisture condensation.

Handling precautions: Use only in a fume hood. Wear chemical-resistant gloves (tested against EN 374 or equivalent), safety goggles, and a lab coat. Avoid generating dust or aerosols. Do not eat, drink, or smoke in work areas. After handling, wash hands thoroughly. Contaminated clothing should be removed and washed before reuse. Refer to the Safety Data Sheet (SDS) for complete safety information.

Shelf life: When stored at –20°C in a sealed, dry container under inert atmosphere, Boc-β-(3-pyridyl)-Ala-OH maintains stability for extended periods. Batch-specific stability data is available upon request.

Product Quality Assurance

Cosperpharm has established a comprehensive quality assurance system for Boc-β-(3-pyridyl)-Ala-OH that meets the rigorous expectations of peptide synthesis and pharmaceutical research applications:

Thorough analytical characterization. Each batch undergoes multi-technique analytical release testing: TLC purity verification (≥99.0%), optical rotation measurement ([α]₂₀/D +15.5 ± 1°, c = 1% in ethanol) for enantiomeric purity confirmation, melting point verification (136–142°C), appearance verification (white to off-white to pale yellow crystalline powder), and where applicable, ¹H NMR and MS confirmation of molecular identity.

Full batch traceability with retention samples. From raw material procurement through synthesis, purification, drying, and final packaging, every step is fully documented and traceable. Each batch receives a unique lot number with sufficient retention samples maintained in accordance with Cosperpharm quality procedures.

Stability monitoring program. Cosperpharm conducts ongoing stability studies under recommended storage conditions (–20°C), with accelerated stability studies conducted on representative batches. Stability summaries are available to support customer research and regulatory submissions.

Documentation ready for your research. Every shipment includes a Certificate of Analysis (COA) with batch-specific purity and characterization data, a Safety Data Sheet (SDS), and customs documentation for international delivery. For customers integrating Boc-β-(3-pyridyl)-Ala-OH into drug development programs, Cosperpharm provides comprehensive documentation packages upon request.

Customer-initiated quality audits. Qualified customers are welcome to audit Cosperpharm's manufacturing, quality control, and documentation facilities. Please contact our regulatory team to schedule an audit.

Contact Us

Searching for high-quality Boc-β-(3-pyridyl)-Ala-OH or other unnatural amino acid building blocks for your peptide synthesis or drug discovery program? Cosperpharm is your trusted partner — with rigorous quality control, comprehensive documentation, and responsive customer support. Get in touch today to discuss your requirements, request a quote, or speak with our technical team.