Boc-Arg-OH.H2O.HCl

Boc-Arg-OH·H₂O·HCl is a cornerstone building block in peptide synthesis, enabling the controlled incorporation of arginine residues into synthetic peptides and proteins. The Boc group on Boc-Arg-OH·H₂O·HCl protects the α-amino group during chain assembly, allowing for selective coupling reactions without unwanted side reactions. The hydrochloride salt form of Boc-Arg-OH·H₂O·HCl enhances solubility in polar solvents, facilitating its use in both solid-phase and solution-phase peptide synthesis. Boc-Arg-OH·H₂O·HCl is widely applied in research studying nitric oxide synthase pathways and metabolic enzyme interactions, contributing to advancements in biochemical methodologies. As a methyl-arginine analog, Boc-Arg-OH·H₂O·HCl is thought to be a primary endogenous agonist for the guanyl cyclase C receptor and is used in simulations of potential drug targets for cancer therapy. The compound presents as a white to almost white powder to crystal with a melting point of 176–178 °C and a specific rotation of [α]²⁰/D −7.0 to −9.0° (c = 2, H₂O). For researchers engaged in peptide therapeutic development, nitric oxide research, or cancer target discovery, Boc-Arg-OH·H₂O·HCl provides the protection, solubility, and purity essential for achieving high-quality results.

Product Parameters

Product Advantages

 Essential Building Block for Arginine-Containing Peptides

Boc-Arg-OH·H₂O·HCl enables the controlled incorporation of arginine residues into synthetic peptides and proteins. The guanidinium side chain of arginine plays critical roles in peptide bioactivity—including hydrogen bonding, electrostatic interactions, and nitric oxide synthase recognition—making this building block essential for the synthesis of biologically active peptides.

 Boc Protection for Selective Peptide Assembly

The Boc group on Boc-Arg-OH·H₂O·HCl protects the α-amino group during chain assembly, allowing for selective coupling reactions without unwanted side reactions. The Boc group is readily removed under mild acidic conditions (TFA), providing a clean deprotection pathway for peptide synthesis.

 Enhanced Solubility via Hydrochloride Salt Form

The hydrochloride salt form of Boc-Arg-OH·H₂O·HCl enhances solubility in polar solvents, facilitating incorporation into various peptide sequences. This improved solubility is a significant practical advantage over the free base form, enabling broader compatibility with both solid-phase and solution-phase peptide synthesis.

 Versatile Applications in Pharmaceutical Research

Boc-Arg-OH·H₂O·HCl is widely applied in research studying nitric oxide synthase pathways and metabolic enzyme interactions. As a methyl-arginine analog, it is thought to be a primary endogenous agonist for the guanyl cyclase C receptor and is used in simulations of potential drug targets for cancer therapy, including tumor suppressor genes and transcription factors.

 High Purity and Well-Defined Properties

Boc-Arg-OH·H₂O·HCl is available at ≥98.0% purity and presents as a white to almost white powder to crystal with a well-defined melting point of 176–178 °C and a specific rotation of [α]²⁰/D −7.0 to −9.0°. These well-characterized properties ensure reproducible performance in peptide synthesis applications.

 Stable Under Recommended Storage

Boc-Arg-OH·H₂O·HCl is stable when stored at room temperature in a cool, dark place or at −20 °C, providing reliable performance over extended periods when handled properly.

Storage Conditions

Store Boc-Arg-OH·H₂O·HCl in a tightly sealed, desiccated container at room temperature in a cool, dark place (<15 °C) or at −20 °C. Keep the container protected from moisture and light. The compound is stable under recommended storage conditions.

Shelf life: Long-term stability is maintained when stored under recommended conditions in a tightly sealed, desiccated container.

Handling precautions: Use in a fume hood. Wear chemical-resistant gloves, safety goggles, and a lab coat. Avoid generating dust. After handling, wash hands thoroughly. Refer to the Safety Data Sheet (SDS) for complete safety information.

Quality Assurance at Cosperpharm

 Gas chromatography (GC) – purity ≥97.0%

 Non‑aqueous titration – purity ≥97.0%

 Refractive index – confirmatory analysis

 ¹H NMR – structural verification

 Appearance – colorless to light yellow to light orange clear liquid

A comprehensive COA, MSDS (with full GHS information), and certificate of origin accompany every shipment.

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