Boc-D-Phe-Pro-Arg-Pro-OH.HCl is a protected tetrapeptide building block that serves as a valuable intermediate in peptide-based drug discovery and medicinal chemistry research. The sequence D-Phe-Pro-Arg-Pro of Boc-D-Phe-Pro-Arg-Pro-OH.HCl represents a conformationally constrained scaffold, with the two proline residues introducing significant rigidity and pre-organizing the peptide backbone for optimal target binding. The D-phenylalanine residue in Boc-D-Phe-Pro-Arg-Pro-OH.HCl contributes to enhanced proteolytic stability, while the arginine side chain provides a cationic guanidinium group that is often critical for electrostatic interactions with biological targets. The Boc protection at the N-terminus of Boc-D-Phe-Pro-Arg-Pro-OH.HCl allows for controlled deprotection and subsequent coupling to other molecular entities, making Boc-D-Phe-Pro-Arg-Pro-OH.HCl a versatile building block for the construction of larger peptide sequences, peptide-drug conjugates, and peptide-based probes for biological studies.
Product Parameters
|
Parameter |
Specification |
|
Product Name |
Boc-D-Phe-Pro-Arg-Pro-OH.HCl |
|
CAS Number |
1213774-15-2 |
|
Molecular Formula |
C30H45CIN7O7 |
|
Molecular Weight |
652.19 g/mol (calculated) |
|
Advantage |
Detail |
|
Production Strength |
GMP-certified campus spanning 100+ mu, 3 multi-purpose workshops, 6 D-grade clean zone production lines, and 150+ reactors (20L–5000L), supporting high/low temp, anaerobic & hydrogenation; kg to ton scale production. |
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Fast Delivery |
R&D samples: one week; commercial orders: 1–2 months after payment. Express (DHL/FedEx) or air/sea freight available. |
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Global Partners |
Trusted by 30+ pharmaceutical companies in USA, Europe, India, Brazil, and Southeast Asia; long-term cooperation with generic drug manufacturers, CROs, and impurity standard distributors. |
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Licensed Exporter |
Valid drug import/export license — no compliance delays. |
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Dual Quality Grades |
Both research/pharma grade（≥98%）and high-purity impurity grade（≥99%）available to meet diverse customer needs. |
Quality Assurance at Cosperpharm
Each batch undergoes:
Gas chromatography (GC) – purity ≥97.0%
Non‑aqueous titration – purity ≥97.0%
Refractive index – confirmatory analysis
¹H NMR – structural verification
Appearance – colorless to light yellow to light orange clear liquid
A comprehensive COA, MSDS (with full GHS information), and certificate of origin accompany every shipment.
FAQ
Q1: What is the sequence of Boc-D-Phe-Pro-Arg-Pro-OH.HCl?
A: The sequence is Boc-D-Phe-Pro-Arg-Pro-OH, consisting of N-terminal Boc protection, followed by D-phenylalanine, L-proline, L-arginine, L-proline, and a free C-terminal carboxylic acid.
Q2: What is the significance of the D-phenylalanine residue?
A: The D-configuration at the phenylalanine residue of Boc-D-Phe-Pro-Arg-Pro-OH.HCl confers proteolytic resistance to peptides incorporating this sequence. D-amino acid-containing peptides are resistant to enzymatic degradation, resulting in enhanced metabolic stability — a critical feature for peptide therapeutics.
Contact Us
Looking for Boc-D-Phe-Pro-Arg-Pro-OH.HCl or other specialized peptide building blocks for your drug discovery program? Cosperpharm is here to help — with expert synthesis, rigorous quality control, and responsive customer support. Contact us today to discuss your requirements or request a quote.
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No. 2 Yangguang 3rd Road, Duodao Chemical Cycle Industrial Park, Jingmen City, Hubei Province, China
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