Boc-D-Phe-Pro-Arg-Pro-OH.HCl

Boc-D-Phe-Pro-Arg-Pro-OH.HCl is a protected tetrapeptide building block that serves as a valuable intermediate in peptide-based drug discovery and medicinal chemistry research. The sequence D-Phe-Pro-Arg-Pro of Boc-D-Phe-Pro-Arg-Pro-OH.HCl represents a conformationally constrained scaffold, with the two proline residues introducing significant rigidity and pre-organizing the peptide backbone for optimal target binding. The D-phenylalanine residue in Boc-D-Phe-Pro-Arg-Pro-OH.HCl contributes to enhanced proteolytic stability, while the arginine side chain provides a cationic guanidinium group that is often critical for electrostatic interactions with biological targets. The Boc protection at the N-terminus of Boc-D-Phe-Pro-Arg-Pro-OH.HCl allows for controlled deprotection and subsequent coupling to other molecular entities, making Boc-D-Phe-Pro-Arg-Pro-OH.HCl a versatile building block for the construction of larger peptide sequences, peptide-drug conjugates, and peptide-based probes for biological studies.

Product Parameters

Quality Assurance at Cosperpharm

Each batch undergoes:

 Gas chromatography (GC) – purity ≥97.0%

 Non‑aqueous titration – purity ≥97.0%

 Refractive index – confirmatory analysis

 ¹H NMR – structural verification

 Appearance – colorless to light yellow to light orange clear liquid

A comprehensive COA, MSDS (with full GHS information), and certificate of origin accompany every shipment.

FAQ

Q1: What is the sequence of Boc-D-Phe-Pro-Arg-Pro-OH.HCl?

A: The sequence is Boc-D-Phe-Pro-Arg-Pro-OH, consisting of N-terminal Boc protection, followed by D-phenylalanine, L-proline, L-arginine, L-proline, and a free C-terminal carboxylic acid.

Q2: What is the significance of the D-phenylalanine residue?

A: The D-configuration at the phenylalanine residue of Boc-D-Phe-Pro-Arg-Pro-OH.HCl confers proteolytic resistance to peptides incorporating this sequence. D-amino acid-containing peptides are resistant to enzymatic degradation, resulting in enhanced metabolic stability — a critical feature for peptide therapeutics.

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Looking for Boc-D-Phe-Pro-Arg-Pro-OH.HCl or other specialized peptide building blocks for your drug discovery program? Cosperpharm is here to help — with expert synthesis, rigorous quality control, and responsive customer support. Contact us today to discuss your requirements or request a quote.