Boc-L-Homophe-OH

Boc-L-Homophe-OH is a cornerstone building block in Boc solid-phase peptide synthesis (Boc-SPPS), serving as a protected precursor for incorporating L-homophenylalanine residues into synthetic peptides and peptidomimetics. The Boc group in Boc-L-Homophe-OH provides robust protection of the α-amino functionality throughout chain assembly, and can be selectively removed under mild acidic conditions (typically TFA) without disturbing other acid-labile protecting groups. Beyond classical peptide synthesis, Boc-L-Homophe-OH has found application in the preparation of piperidine-containing peptidyl proteasome inhibitors and other biologically active compounds targeting the ubiquitin-proteasome pathway. The unnatural homophenylalanine motif introduced by Boc-L-Homophe-OH has been incorporated into numerous drug discovery programs, including the development of protease inhibitors and receptor-targeted therapeutics where the extended hydrophobic side chain enhances binding affinity and metabolic stability.

Product Parameters

Why Cosperpharm?

When your peptide synthesis campaign demands reliable Boc-protected amino acid building blocks with consistent quality and comprehensive documentation, Cosperpharm delivers Boc-L-Homophe-OH with the analytical rigor that pharmaceutical and biotech researchers require.

Purity you can trust. Our Boc-L-Homophe-OH is released with ≥98.0% purity verified by TLC, with full chromatographic traceability. Each batch undergoes identity confirmation by optical rotation [α]²⁰/D +6.5±1° (c = 2% in ethanol), melting point verification (76–80 °C), and appearance inspection — because the success of your solid-phase peptide synthesis depends on the quality of each building block.

Documentation that supports your research. Every shipment includes a Certificate of Analysis (COA) with batch-specific purity data, optical rotation, and characterization results. For customers requiring regulatory support, custom quality agreements and additional documentation packages are available upon request.

Flexible supply for every scale. Cosperpharm supplies Boc-L-Homophe-OH across the full range of applications — from 1g–5g quantities for research and medicinal chemistry discovery, to larger batches for process development and custom synthesis campaigns. R&D samples ship within 5–7 business days.

Technical support from peptide chemists. Our team understands the nuances of Boc-SPPS and can advise on deprotection conditions, coupling strategies, and compatibility with various resin systems — because we have extensive experience with this building block across multiple peptide synthesis campaigns.

Global reach with transparent pricing. Cosperpharm ships to pharmaceutical manufacturers, CROs, and academic research laboratories worldwide, with full customs documentation included.

Storage Conditions

Store Boc-L-Homophe-OH in a tightly sealed container at 2–8 °C in a dry, well-ventilated area. The compound is hygroscopic and heat-sensitive; storage under inert gas (nitrogen or argon) is recommended to prevent moisture absorption and degradation. Protect from light and keep away from strong oxidizing agents. Allow the sealed container to reach ambient temperature before opening to minimize moisture condensation.

Handling precautions: Use only in a fume hood. Wear chemical-resistant gloves, safety goggles, and a lab coat. Avoid generating dust. After handling, wash hands thoroughly. Refer to the Safety Data Sheet (SDS) for complete safety information.

Contact Us

Ready to secure Boc-L-Homophe-OH for your next peptide synthesis campaign or drug discovery program? Cosperpharm makes it straightforward. Reach out to our team for pricing, documentation, or technical support — we‘re here to help you move your research forward.