Boc-Val-OH

Boc-Val-OH is a cornerstone reagent in modern peptide synthesis and pharmaceutical development. As a protected amino acid monomer, Boc-Val-OH enables the selective introduction of valine residues into peptide chains without interference from the amino functionality. Boc-Val-OH serves as the standard building block for incorporating valine amino-acid residues by Boc solid-phase peptide synthesis (Boc SPPS). Beyond peptide chemistry, Boc-Val-OH is a critical chiral intermediate for the synthesis of enantiopure pharmaceuticals, including the antiviral agents valacyclovir and valganciclovir. The compound's high purity (≥99.0%) and well-characterized optical rotation make Boc-Val-OH an indispensable reagent for both research and industrial-scale peptide manufacturing.

Product Parameters

Why Cosperpharm?

Purity that ensures peptide fidelity. The quality of your protected amino acid directly determines the success of your peptide assembly. Any impurity in Boc-Val-OH can lead to deletion sequences, truncated products, or racemization that compromise your final peptide's biological activity. Our analytical release protocol includes neutralization titration (≥99.0%), melting point verification, specific rotation confirmation, and NMR structural verification — because your peptide synthesis depends on the quality of this building block.

Documentation that supports regulatory and research needs. Every shipment includes a Certificate of Analysis (COA) with batch-specific purity, optical rotation, and characterization data. For customers preparing regulatory submissions or quality documentation, stability summaries and custom quality agreements are available upon request.

Flexible supply across all scales. Cosperpharm supplies Boc-Val-OH from gram-scale R&D quantities for peptide library synthesis and method development to kilogram-scale bulk quantities for commercial peptide manufacturing and pharmaceutical intermediate production. R&D samples ship within 5–7 business days; bulk orders ship within 2–3 weeks.

Technical support for the full synthetic workflow. Our process chemistry team can advise on Boc deprotection conditions, coupling strategies, and compatibility with various peptide synthesis platforms — because we have worked extensively with this protected amino acid across multiple manufacturing campaigns.

Global reach with transparent pricing. Cosperpharm ships to pharmaceutical manufacturers, CROs, and research institutions worldwide, with full customs documentation included. Volume discounts apply at larger scales, and we communicate lead times upfront.

Application

Used in peptide synthesis as an amino acid protecting monomer. Flumetsulamide intermediate

For use in biochemical reagents, synthesis of side chains for the lopivoxil series such as valacyclovir or valganciclovir, and peptide synthesis.

Synthetic Route

Using tert-butylcarbonyl azide and L-valine as starting materials, a crude product was obtained via acylation under alkaline conditions, followed by extraction with ether and ethyl acetate, and purification by recrystallization to yield the final product.

Contact Us

Need Boc-Val-OH for your peptide synthesis project or pharmaceutical intermediate manufacturing? Cosperpharm is ready to supply the quality and documentation you require. Reach out to our team today to discuss your specifications, request a quote, or schedule a consultation.