C13-112-tetra-tail

C13-112-tetra-tail is an ionizable cationic lipid containing a polar amino alcohol head group, four hydrophobic C13 tails, and a PEG2 linker, making it suitable for formulation into lipid nanoparticles (LNPs) for advanced nucleic acid delivery applications. C13-112-tetra-tail can be formulated into LNPs to deliver anionic substrates in vitro and in vivo, including siRNA for sequence‑specific gene silencing, Cas9 mRNA for genome editing, and cytotoxic proteins for therapeutic applications.The four‑tail architecture of C13-112-tetra-tail provides enhanced hydrophobic volume compared to traditional two‑tail ionizable lipids, potentially improving nucleic acid encapsulation efficiency and LNP stability. C13-112-tetra-tail represents an advanced generation of cationic lipid‑like compounds designed to address the demanding requirements of mRNA therapeutics, gene silencing platforms, and protein delivery systems.

Product Parameters

Product Advantages

1. Four‑Tail Architecture for Enhanced Hydrophobic Volume

C13-112-tetra-tail features four hydrophobic carbon‑13 tails radiating from a central tertiary amine core — a departure from conventional two‑tail ionizable lipids. This multi‑tail design increases the hydrophobic volume of the lipid core within LNPs, potentially improving nucleic acid encapsulation efficiency and contributing to more stable nanoparticle structures that resist premature payload leakage during circulation.

2. PEG2 Linker for Colloidal Stability and Steric Shielding

The PEG2 linker in C13-112-tetra-tail provides a short polyethylene glycol spacer that enhances hydrophilicity and contributes to the colloidal stability of LNP formulations. The PEG moiety reduces opsonization and non‑specific protein adsorption, supporting prolonged circulation time and improved biocompatibility for in vivo applications.

3. Ionizable Amino Alcohol Head Group for Endosomal Escape

The polar amino alcohol head group of C13-112-tetra-tail enables pH‑dependent protonation — cationic at physiological pH for electrostatic complexation with anionic nucleic acids, and neutral or weakly cationic in the acidic environment of endosomes (pH 5.5–6.5). This tunable ionization behavior facilitates endosomal membrane disruption and cytosolic release of encapsulated payloads, a critical determinant of therapeutic efficacy for nucleic acid‑based drugs.

4. Versatile Nucleic Acid and Protein Delivery Platform

C13-112-tetra-tail can be formulated into LNPs to deliver a diverse range of anionic substrates — including siRNA for sequence‑specific gene silencing, Cas9 mRNA for genome editing, and cytotoxic proteins for targeted therapeutic applications — positioning it as a versatile tool for multiple modalities within the nucleic acid therapeutics space.

5. Established LNP Compatibility

C13-112-tetra-tail is recognized as a standard ionizable cationic lipid for LNP formulation, with documented compatibility with standard microfluidic mixing and thin‑film hydration preparation methods. Its solubility profile in ethanol, DMSO, and DMF supports standard LNP formulation workflows.

Quality Assurance at Cosperpharm

Each batch undergoes:

● Gas chromatography (GC) – purity ≥97.0%

● Non‑aqueous titration – purity ≥97.0%

● Refractive index – confirmatory analysis

● ¹H NMR – structural verification

● Appearance – colorless to light yellow to light orange clear liquid

A comprehensive COA, MSDS (with full GHS information), and certificate of origin accompany every shipment.

FAQ

Q1: How should C13-112-tetra-tail be stored?

A: Store the powder at −20 °C, where it is stable for up to 3 years. For stock solutions, store at −80 °C for up to 6 months or at −20 °C for up to 1 month. Avoid repeated freeze‑thaw cycles.

Q2: Is C13-112-tetra-tail suitable for GMP applications?

A: GMP‑grade inquiries are available upon request. For research use only — not for human or veterinary therapeutic use.

Contact Us

Cosperpharm is your trusted source for C13-112-tetra-tail and other ionizable lipids for LNP formulation research. Whether you need milligram quantities for screening or larger volumes for preclinical studies, our team is ready to support your work with quality products and responsive service. Contact Cosperpharm today to discuss your requirements.