Fmoc-3,3-Diphenylalanine

Fmoc-3,3-Diphenylalanine (Fmoc-L-Ala(3,3-diphenyl)-OH) is a modified amino acid derivative that delivers distinctive rigidity and steric bulk to peptide sequences, making it particularly valuable for studying conformational constraints and protein‑protein interactions. The 3,3-diphenyl substitution of Fmoc-3,3-Diphenylalanine enhances peptide stability against proteolytic degradation and induces predictable folding patterns, a property that has been exploited in the design of β‑turn mimics and other secondary structure-inducing elements. Fmoc-3,3-Diphenylalanine is an alanine derivative with diverse applications in peptide synthesis, structural biology, drug development, and materials science. The Fmoc protecting group on Fmoc-3,3-Diphenylalanine allows selective deprotection strategies, making this compound indispensable for solid-phase peptide synthesis where orthogonal protection schemes are required

Product Parameters

Safety Information Summary

Storage Conditions

Store Fmoc-3,3-Diphenylalanine at 2–8 °C in a tightly sealed container, protected from light and moisture. Keep the container dry and stored in a clean, well‑ventilated area away from strong oxidizing agents, strong bases, and sources of ignition. The compound is stable under recommended storage conditions and is not classified as a combustible solid (Storage Class 13 — Non‑Combustible Solids). Allow the sealed container to reach ambient temperature before opening to minimize moisture condensation.

Shelf life: 2–3 years when stored at 2–8 °C in a sealed container under recommended conditions. Accelerated stability data and long‑term stability summaries are available upon request to support customer quality documentation.

Handling precautions: Use in a fume hood. Wear chemical‑resistant gloves (tested against EN 374 or equivalent), safety goggles, and a lab coat. Avoid generating dust or aerosols. Do not eat, drink, or smoke in work areas. After handling, wash hands thoroughly. Contaminated clothing should be removed and washed before reuse. Refer to the Safety Data Sheet (SDS) for complete safety information.

Product Quality Assurance

Cosperpharm has established a comprehensive quality assurance system for Fmoc-3,3-Diphenylalanine that meets the rigorous expectations of both research and commercial peptide manufacturing applications:

Thorough analytical characterization. Each batch undergoes multi‑technique analytical release testing: HPLC purity (≥98% industrial grade; ≥99.5% reference grade, with full chromatographic traceability), chiral HPLC verification for enantiomeric purity, optical rotation verification ([α]²⁰D = −24 ± 4°, c=1 in DMF), melting point verification (125–129 °C), appearance verification (white to off‑white powder), and identity confirmation.

Full batch traceability with retention samples. From raw material procurement through Fmoc protection, purification, and final packaging, every step is fully documented and traceable. Each batch receives a unique lot number with sufficient retention samples maintained in accordance with Cosperpharm quality procedures.

Stability monitoring program. Cosperpharm conducts ongoing stability studies under recommended storage conditions (2–8 °C, sealed container, dry environment). Stability summaries are updated regularly, with full data packages available to support customer quality documentation.

Documentation ready for your records. Every shipment includes a Certificate of Analysis (COA) with batch‑specific purity and characterization data, a Material Safety Data Sheet (SDS), and customs documentation for international delivery. For customers preparing documentation for regulated environments, Cosperpharm provides custom quality agreements, DMF‑ready documentation packages, and method validation reports upon request. Traceability against USP or EP pharmacopeial standards can be provided where feasible.

Customer‑initiated quality audits. Qualified customers are welcome to audit Cosperpharm‘s manufacturing, quality control, and documentation facilities. Please contact our regulatory team to schedule an audit. ISO compliance documentation is available upon request.

Contact Us

Whether you are designing a conformationally constrained peptide, developing a protease‑resistant therapeutic, or exploring self‑assembling biomaterials, Cosperpharm is your trusted partner for Fmoc-3,3-Diphenylalanine. Contact us today for product specifications, pricing, technical support, or to discuss custom packaging options. Our team is ready to support your research and production needs with responsive service and reliable quality.