Fmoc-beta-HGlu(OtBu)-OH

Fmoc-beta-HGlu(OtBu)-OH is a pivotal building block in Fmoc/t-Bu solid-phase peptide synthesis, enabling the incorporation of β-homoglutamic acid residues into peptide sequences. The Fmoc group of Fmoc-beta-HGlu(OtBu)-OH serves as a base-labile protecting group for the amino function, while the tert-butyl ester protects the side-chain carboxyl function during synthesis. This orthogonal protection strategy of Fmoc-beta-HGlu(OtBu)-OH allows for selective deprotection and functionalization during peptide assembly, preventing unwanted side reactions. Peptides synthesized with Fmoc-beta-HGlu(OtBu)-OH are studied for their roles in protein-protein interactions, enzyme-substrate recognition, and cellular signaling pathways. As a commercially available reagent, Fmoc-beta-HGlu(OtBu)-OH is offered with purity ≥95% and is widely used in pharmaceutical peptide API production.

Product Parameters

Product Advantages

1. β-Amino Acid Building Block for Extended Peptide Chains

Fmoc-beta-HGlu(OtBu)-OH incorporates a β-homoglutamic acid residue that extends the peptide backbone by one carbon atom compared to standard glutamic acid. This β-amino acid geometry provides unique conformational properties and can significantly influence peptide structural and functional characteristics.

2. Orthogonal Protection Strategy

The Fmoc group protects the amino function and is removed by piperidine treatment, while the tert-butyl ester protects the side-chain carboxyl and is removed by acidolysis. This orthogonal protection enables selective deprotection during SPPS.

3. Versatile Solubility Profile

The β-homoglutamic acid backbone of Fmoc-beta-HGlu(OtBu)-OH supports variable solubility profiles, serving researchers in dynamic metabolism and biosynthesis investigations. The compound is slightly soluble in water, making it compatible with aqueous reaction systems when needed.

4. Validated for Peptide-Based Therapeutics

Peptides derived from Fmoc-beta-HGlu(OtBu)-OH are being explored for therapeutic applications including peptide-based drug development, vaccine formulation, and treatments for diseases involving peptide hormones or neurotransmitters.

5. High Purity with Full Characterization

Cosperpharm supplies Fmoc-beta-HGlu(OtBu)-OH with HPLC purity ≥95%, confirmed by optical rotation and other analytical methods. Each batch is accompanied by a comprehensive COA documenting purity, optical rotation, and identity.

Storage Conditions

Store Fmoc-beta-HGlu(OtBu)-OH in a tightly sealed container at 2–8 °C. Keep the container dry, protected from light, and stored in a clean, well-ventilated area away from strong oxidizing agents. The compound is stable under recommended storage conditions. Allow the sealed container to reach ambient temperature before opening to minimize moisture condensation.

Shelf life: Stable for extended periods when stored at 2–8 °C in a sealed, dry container. Please refer to the Certificate of Analysis for batch-specific expiration dating.

Handling precautions: Use only in a fume hood. Wear chemical-resistant gloves, safety goggles, and a lab coat. Avoid generating dust or aerosols. Do not eat, drink, or smoke in work areas. After handling, wash hands thoroughly. Refer to the Safety Data Sheet (SDS) for complete safety information.

Product Quality Assurance

Cosperpharm has established a comprehensive quality assurance system for Fmoc-beta-HGlu(OtBu)-OH that meets the rigorous expectations of peptide synthesis and pharmaceutical research applications:

Thorough analytical characterization. Each batch undergoes multi-technique analytical release testing: HPLC purity (≥95% with full chromatographic traceability), optical rotation verification ([α]²⁵D = −11 ± 2.5° in CHCl₃), melting point determination (115–120 °C), appearance verification (white to off-white powder), and identity confirmation.

Full batch traceability with retention samples. From raw material procurement through protection reactions, purification, and final packaging, every step is fully documented and traceable. Each batch receives a unique lot number with sufficient retention samples maintained in accordance with Cosperpharm quality procedures.

Stability monitoring program. Cosperpharm conducts ongoing stability studies under recommended storage conditions (0–8 °C). Stability summaries are available upon request to support customer regulatory submissions.

Documentation ready for regulatory submission. Every shipment includes a Certificate of Analysis (COA) with batch-specific purity and characterization data, a Safety Data Sheet (SDS), and customs documentation for international delivery. For customers developing peptide-based therapeutics, Cosperpharm provides custom quality agreements and comprehensive documentation packages upon request.

Customer-initiated quality audits. Qualified customers are welcome to audit Cosperpharm‘s manufacturing, quality control, and documentation facilities. Please contact our regulatory team to schedule an audit.

Contact Us

Need Fmoc-beta-HGlu(OtBu)-OH for your next peptide synthesis or therapeutic development project? Cosperpharm is here to help with reliable supply and expert support.