Fmoc-Lys(Alloc)-OH

Fmoc-Lys(Alloc)-OH is a premium orthogonal protecting group reagent widely adopted in advanced peptide synthesis workflows. Fmoc-Lys(Alloc)-OH serves as an orthogonally-protected building block for the synthesis of branched and cyclic peptides as well as peptides modified at the lysine side chain by Fmoc SPPS. The Alloc group on Fmoc-Lys(Alloc)-OH can be selectively removed in the presence of standard Fmoc- and tert-butyl-based protecting groups by treatment with Pd(PPh₃)₄/CHCl₃/AcOH/NMM, enabling post-assembly side‑chain functionalization. Fmoc-Lys(Alloc)-OH has been employed in the solid-phase synthesis of liraglutide, where the Alloc-protected lysine residue is incorporated and subsequently deprotected for conjugation with fatty acid side chains. With its high purity specifications (≥98% HPLC) and rigorous quality control, Fmoc-Lys(Alloc)-OH meets the demanding requirements of pharmaceutical peptide manufacturing and research-grade applications.

Product Parameters

Why Cosperpharm?

Your peptide synthesis campaign deserves building blocks you can trust — from the first coupling to the final deprotection. Cosperpharm delivers Fmoc-Lys(Alloc)-OH with the rigorous quality control, technical documentation, and flexible supply options that pharmaceutical and biotech researchers demand.

Orthogonal protection demands purity. The Alloc group must survive multiple Fmoc deprotection cycles before its eventual Pd(0)-mediated removal. Any impurity in Fmoc-Lys(Alloc)-OH — particularly premature Alloc cleavage or Fmoc deletion — will compromise your branching strategy or side‑chain conjugation plan. Every batch we ship undergoes HPLC purity verification (≥98%), water content analysis (Karl Fischer), enantiomeric purity assessment (≥99.5%), and identity confirmation. Your complex peptide architecture depends on this quality foundation.

Documentation built for regulatory submissions. For customers developing peptide APIs or ANDA filings, every reference‑grade shipment includes a Certificate of Analysis (COA) with batch‑specific HPLC purity, optical rotation, TLC traceability, and water content data — structured for direct integration into your method validation package. Stability summaries, custom quality agreements, and DMF‑ready documentation are available upon request.

Supply that matches your workflow. Cosperpharm supplies Fmoc-Lys(Alloc)-OH across the full range of applications — from 1g–25g research quantities for method development and screening, to 100g–500g batches for process validation, to kilogram‑scale drums for commercial peptide manufacturing. R&D samples ship within 3–5 business days; bulk orders ship within 2 weeks.

Technical support you can rely on. Our process chemistry team can advise on Alloc deprotection conditions (Pd(PPh₃)₄ in CHCl₃/AcOH/NMM), compatibility with various resin systems, and analytical methods for detecting process‑related impurities — because we have extensive experience with orthogonal protection strategies across numerous peptide manufacturing campaigns.

Global logistics with transparent pricing. Cosperpharm ships to peptide synthesis facilities, CROs, and pharmaceutical manufacturers worldwide, with complete customs documentation included. Volume discounts apply at kilogram scales, and we communicate lead times upfront — no surprises, no delays.

Synthetic Route

Fmoc-Lys(Alloc)-OH is typically synthesized from L‑lysine through a multi‑step orthogonal protection strategy. The α‑amino group is first protected with the Fmoc group under Schotten‑Baumann conditions using Fmoc‑OSu or Fmoc‑Cl in aqueous sodium carbonate. The ε‑amino group is then protected with the Alloc group using allyl chloroformate in the presence of a base. Careful control of reaction conditions ensures orthogonal protection without cross‑reactivity between the two protecting groups. The final product is isolated by extraction, purified by recrystallization or flash chromatography, and characterized by HPLC, TLC, and optical rotation.

Storage Conditions

Shelf life: 3 years when stored at –20 °C in a sealed container under inert atmosphere; 2 years when stored at 4 °C. Stability summaries are available upon request to support regulatory filings.

Handling precautions: Use in a fume hood. Wear chemical‑resistant gloves, safety goggles, and a lab coat. Avoid generating dust. Do not eat, drink or smoke in work areas. After handling, wash hands thoroughly. Refer to the Safety Data Sheet (SDS) for complete safety information.

Contact Us

Need a trusted supply of Fmoc-Lys(Alloc)-OH for your next peptide synthesis campaign or regulatory filing? Cosperpharm is here to help. Reach out to our sales team for quotes, documentation requests, or technical inquiries — we will respond promptly and provide the support you need to keep your project moving forward.