Fmoc-Lys(C16-OtBu)-OH

Fmoc-Lys(C16-OtBu)-OH is a specialized Fmoc-protected lysine derivative featuring a C16 long-chain fatty acid modification on the ε-amino group, designed for the synthesis of lipidated peptides and peptide amphiphiles. This compound belongs to the class of Fmoc-amino acid derivatives with extended alkyl chains, where the palmitoyl (C16) moiety imparts lipophilic character that enables membrane anchoring, self-assembly, and enhanced cellular uptake of peptide-based constructs. Fmoc-Lys(C16-OtBu)-OH serves as a key building block in the synthesis of lipidated peptides for drug delivery applications, vaccine development, and membrane protein studies. The tert-butyl ester protection on the C-terminus of Fmoc-Lys(C16-OtBu)-OH provides orthogonal compatibility with standard Fmoc SPPS protocols, allowing for selective deprotection and further functionalization. Fmoc-Lys(C16-OtBu)-OH is supplied with rigorous analytical characterization ensuring high purity and consistent performance in peptide synthesis applications.

Product Parameters

 Why Cosperpharm?

When your peptide amphiphile program or lipidated peptide synthesis requires specialized building blocks like Fmoc-Lys(C16-OtBu)-OH, Cosperpharm delivers with the quality, technical expertise, and supply flexibility that advanced research demands.

Specialized building blocks require specialized suppliers. Fmoc-Lys(C16-OtBu)-OH is not a standard Fmoc-amino acid — it is a specialized derivative combining a lipophilic C16 chain with orthogonal protecting groups. Cosperpharm understands the unique challenges of synthesizing and handling lipidated amino acid derivatives and provides the technical support needed for successful peptide synthesis.

Documentation for research confidence. Every shipment of Fmoc-Lys(C16-OtBu)-OH includes a Certificate of Analysis (COA) with batch-specific purity data. Custom quality documentation is available upon request for customers with specific requirements.

Flexible supply for all research stages. Cosperpharm supplies Fmoc-Lys(C16-OtBu)-OH from gram-scale quantities for exploratory research to larger batches for process development. R&D samples ship within 7–10 business days.

Technical support for lipidated peptide synthesis. Our team can advise on coupling conditions for lipophilic amino acid derivatives, solubility considerations, and purification strategies for lipidated peptides — because we have experience with this challenging class of compounds.

Product Advantages

 Lipophilic C16 Chain for Membrane Interactions

The C16 (palmitoyl) moiety of Fmoc-Lys(C16-OtBu)-OH enables the synthesis of lipidated peptides with enhanced membrane-binding affinity, cell-penetrating properties, and self-assembly capabilities. This lipophilic modification is essential for the development of membrane-active peptides and peptide-based drug delivery systems.

 Fmoc SPPS Compatibility

Fmoc-Lys(C16-OtBu)-OH is fully compatible with standard Fmoc solid-phase peptide synthesis protocols, enabling efficient incorporation of lipidated lysine residues into peptide sequences. The Fmoc group is cleaved under standard basic conditions, while the C16 modification remains intact throughout synthesis and purification.

 Orthogonal tert-Butyl Ester Protection

The tert-butyl ester protection at the C-terminus of Fmoc-Lys(C16-OtBu)-OH provides orthogonal compatibility with Fmoc SPPS strategies. This protecting group can be selectively removed under acidic conditions (e.g., TFA), enabling site-specific functionalization or conjugation after peptide assembly.

 Versatile Building Block for Peptide Amphiphiles

Fmoc-Lys(C16-OtBu)-OH serves as a versatile building block for the synthesis of peptide amphiphiles — molecules combining a hydrophobic lipid tail with a hydrophilic peptide sequence. These constructs self-assemble into nanostructures (micelles, fibers, vesicles) with applications in drug delivery, tissue engineering, and vaccine development.

Product Quality Assurance

Cosperpharm has established a comprehensive quality assurance system for Fmoc-Lys(C16-OtBu)-OH to support peptide synthesis and lipidated peptide research applications:

Thorough analytical characterization. Each batch undergoes analytical release testing including HPLC purity verification (≥95% typical for research grade), appearance verification, and identity confirmation where applicable.

Full batch traceability. From raw material procurement through synthesis, purification, and final packaging, every step is fully documented and traceable. Each batch receives a unique lot number with retention samples maintained in accordance with Cosperpharm quality procedures.

Documentation for research confidence. Every shipment includes a Certificate of Analysis (COA) with batch-specific purity data and customs documentation for international delivery. Custom quality documentation is available upon request for customers with specific requirements.

Contact Us

Need Fmoc-Lys(C16-OtBu)-OH for your lipidated peptide synthesis or peptide amphiphile program? Cosperpharm is here to help — contact us for pricing, availability, or to discuss your specific requirements.