Fmoc-N-Me-Arg(Pbf)-OH

Fmoc-N-Me-Arg(Pbf)-OH is a premium-grade amino acid derivative engineered specifically for Fmoc-based solid-phase peptide synthesis (SPPS). As a direct building block, Fmoc-N-Me-Arg(Pbf)-OH enables the seamless incorporation of Nα-methyl-L-arginine residues into synthetic peptides, a modification that is increasingly valuable in the development of peptide-based therapeutics with enhanced protease resistance and improved pharmacokinetic properties. Beyond conventional peptide synthesis, Fmoc-N-Me-Arg(Pbf)-OH has found specialized application in the synthesis of neurotensin-derived NTS1 ligands for positron emission tomography (PET) imaging, demonstrating its utility in the development of diagnostic radiopharmaceuticals. The Pbf-protected guanidinium group on Fmoc-N-Me-Arg(Pbf)-OH ensures clean coupling chemistry while being readily removable under standard TFA-mediated cleavage conditions, making this derivative a reliable choice for both research and process-scale peptide manufacturing.

Product Parameters

Product Advantages

1. Enables Nα-Methylated Arginine Incorporation

Fmoc-N-Me-Arg(Pbf)-OH is the definitive building block for introducing Nα-methylated arginine into synthetic peptides. Nα-methylation is a powerful strategy for modulating peptide conformation, enhancing protease resistance, and improving metabolic stability—properties that are increasingly critical in peptide drug development.

2. Superior Pbf Protection for Clean Deprotection

The Pbf (2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl) group on Fmoc-N-Me-Arg(Pbf)-OH offers significant advantages over alternative arginine protections such as Mtr. The Pbf group is removed under much milder acidolytic conditions during global TFA-mediated cleavage, minimizing the risk of side reactions and ensuring high-purity peptide products.

3. Fully Compatible with Fmoc SPPS

Fmoc-N-Me-Arg(Pbf)-OH is engineered for seamless integration into standard Fmoc-based solid-phase peptide synthesis workflows. The base-labile Fmoc group enables efficient deprotection and chain elongation under standard SPPS conditions, while the orthogonal Pbf protection remains stable throughout chain assembly.

4. Specialized Application in PET Imaging

Fmoc-N-Me-Arg(Pbf)-OH has been utilized in the synthesis of neurotensin-derived NTS1 ligands for PET imaging applications. This demonstrates the compound's utility beyond conventional peptide synthesis, extending into the development of diagnostic radiopharmaceuticals for neuroimaging.

5. High Purity for Demanding Applications

Cosperpharm supplies Fmoc-N-Me-Arg(Pbf)-OH with HPLC purity ranging from ≥97% to ≥98.28%, ensuring reliable coupling efficiency and minimizing impurity-related issues in peptide synthesis. Each batch is characterized by optical rotation and identity confirmation.

6. Rigorous Quality Control

Every batch of Fmoc-N-Me-Arg(Pbf)-OH undergoes comprehensive analytical testing, including HPLC purity determination, optical rotation verification, and residual solvent analysis—ensuring consistent quality batch after batch.

FAQ

Q1: What is the primary use of Fmoc-N-Me-Arg(Pbf)-OH?

A: Fmoc-N-Me-Arg(Pbf)-OH is a specialized amino acid derivative used as a building block in Fmoc-based solid-phase peptide synthesis (SPPS) for the incorporation of Nα-methylated arginine residues into synthetic peptides. It is also used in the synthesis of neurotensin-derived NTS1 ligands for PET imaging.

Q2: What purity does Cosperpharm supply?

A: Cosperpharm supplies Fmoc-N-Me-Arg(Pbf)-OH with HPLC purity of ≥97% to ≥98.28%, depending on the grade. Each batch is accompanied by a Certificate of Analysis with batch-specific purity data.

Storage Conditions

Store Fmoc-N-Me-Arg(Pbf)-OH in a tightly sealed container, protected from light, in a dry environment at −20°C for long-term storage. Keep the container tightly closed and stored in a clean, well-ventilated area away from strong oxidizing agents and strong bases. The compound should be protected from moisture and light.

Shelf life: 3 years when stored at −20°C in a sealed container under recommended conditions.

Handling precautions: Use only in a fume hood. Wear chemical-resistant gloves, safety goggles, and a lab coat. Avoid breathing dust or fumes. Avoid dust and aerosol formation. After handling, wash hands thoroughly. This product is for research use only and not for human consumption. Refer to the Safety Data Sheet (SDS) for complete safety information.

Contact Us

Sourcing Fmoc-N-Me-Arg(Pbf)-OH for your peptide synthesis program, drug discovery project, or PET imaging agent development should be straightforward. Cosperpharm makes it simple. Reach out to our team today to discuss your requirements, request a quote, or inquire about bulk pricing and custom documentation.