Fmoc-TmbGly-OH

Fmoc-TmbGly-OH is a high‑value glycine building block engineered specifically to overcome the “difficult sequence” problem in Fmoc solid‑phase peptide synthesis, where the inherent flexibility of glycine residues promotes undesirable intermolecular β‑sheet formation and aggregation on the solid support. Fmoc-TmbGly-OH solves this problem by incorporating the acid‑labile 2,4,6‑trimethoxybenzyl group on the glycine backbone nitrogen, effectively “capping” the amide bond that would otherwise form during chain extension. This strategic backbone protection disrupts the hydrogen‑bonding network responsible for aggregation, allowing the synthesis to proceed with normal deprotection and coupling kinetics. After the full peptide chain has been assembled, the Tmb group is cleanly removed under mildly acidic conditions (e.g., 7% TFA in DCM), restoring the native glycine backbone without compromising other acid‑sensitive side‑chain protections. This makes Fmoc-TmbGly-OH an indispensable tool for peptide chemists working on aggregation‑prone sequences, transmembrane peptides, and other difficult synthetic targets where conventional building blocks fail.

Product Parameters

Why Cosperpharm? – Our Competitive Advantages

Production Strength

  GMP-certified campus spanning 100+ mu, 3 multi-purpose workshops, 6 D-grade clean zone production lines, and 150+ reactors (20L–5000L), supporting high/low temp, anaerobic & hydrogenation; kg to ton scale production.

Fast Delivery

  R&D samples: one week; commercial orders: 1–2 months after payment. Express (DHL/FedEx) or air/sea freight available.

Global Partners

  Trusted by 30+ pharmaceutical companies in USA, Europe, India, Brazil, and Southeast Asia; long-term cooperation with generic drug manufacturers, CROs, and impurity standard distributors.

Licensed Exporter

  Valid drug import/export license — no compliance delays.

Dual Quality Grades

  Both research/pharma grade（≥98%）and high-purity impurity grade（≥99%）available to meet diverse customer needs.

Quality Assurance at Cosperpharm

Each batch undergoes:

  Gas chromatography (GC) – purity ≥97.0%

  Non‑aqueous titration – purity ≥97.0%

  Refractive index – confirmatory analysis

  ¹H NMR – structural verification

  Appearance – colorless to light yellow to light orange clear liquid

A comprehensive COA, MSDS (with full GHS information), and certificate of origin accompany every shipment.

Storage Conditions

Store Fmoc-TmbGly-OH in a tightly sealed container, protected from light, at 2–8 °C for short‑term storage (up to 12 months). For long‑term storage (>12 months), store at –20 °C under an inert atmosphere (nitrogen or argon). Keep the container dry and stored in a clean, well‑ventilated area away from strong oxidizing agents, strong bases, and sources of ignition. The Tmob group is stable under recommended dry storage conditions but should be protected from moisture and strong acids.

Shelf life: 3 years when stored at 4 °C in a sealed container under recommended conditions. Cosperpharm guarantees product integrity for 2 years when stored at –20 °C in a sealed container under inert atmosphere. Stability data are available upon request.

Handling precautions: Use in a fume hood. Wear chemical‑resistant gloves, safety goggles, and a lab coat. Avoid generating dust or aerosols. After handling, wash hands thoroughly. Standard laboratory safety practices should always be followed.

Contact us

Whether you‘re synthesizing a single aggregation‑prone peptide for a structure‑activity study or scaling up a transmembrane therapeutic for clinical development, Fmoc-TmbGly-OH from Cosperpharm provides the backbone protection you need. Reach out to our peptide chemistry specialists today.