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DMT-2'-dA(Bz)-3'-PS-Phosphoramidite |
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DMT-2'-dG(iBu)-3'-PS-Phosphoramidite |
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DMT-2'-dC(Ac)-3'-PS-Phosphoramidite |
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DMT-2'-dT-3'-PS-Phosphoramidite |
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The phosphorothioate (PS) modification is a cornerstone of antisense oligonucleotide (ASO) and siRNA therapeutics. By incorporating a sulfur atom into the phosphate backbone, the resulting oligonucleotide exhibits significantly increased resistance to degradation by cellular nucleases, thereby extending its half-life in vivo. Additionally, the PS backbone enhances binding to plasma proteins, which improves tissue distribution and cellular uptake. Cosperpharma’s DNA-Thiophosphoramidites are specifically designed for the site-specific introduction of PS linkages during solid-phase synthesis. Each monomer is synthesized under strictly controlled anhydrous conditions to ensure optimal coupling efficiency and is rigorously purified to meet the high-purity standards required for therapeutic development.
Precise Control Over Backbone Modification: Our DNA-Thiophosphoramidites allow for the site-specific incorporation of phosphorothioate linkages. This precision is critical for optimizing the balance between nuclease resistance and binding affinity, as excessive PS content can sometimes lead to reduced specificity. Researchers can strategically position these monomers to achieve the desired therapeutic profile.
Superior Coupling Efficiency: The synthesis of phosphorothioate-modified oligonucleotides requires high-quality monomers to ensure complete coupling and minimize failure sequences. Cosperpharma’s thiophosphoramidites are manufactured to exacting standards, delivering reliable and reproducible coupling yields even for longer sequences.
Comprehensive Documentation for Regulatory Support: We understand the stringent requirements of drug development. Therefore, every batch of our DNA-Thiophosphoramidites is accompanied by a detailed Certificate of Analysis (COA) and Safety Data Sheet (SDS). Customized documentation packages are available to support your IND and NDA submissions.
Scalable Supply for Every Stage: From small-scale research and development to large-scale commercial manufacturing, Cosperpharma provides flexible packaging specifications and reliable global delivery to match your project timeline and production needs.
We are committed to being your trusted partner in oligonucleotide therapeutics. If you are interested in evaluating our DNA-Thiophosphoramidites or would like to discuss your specific synthesis challenges with our technical team, we encourage you to get in touch. Contact Cosperpharma today to request a detailed specification sheet, explore our latest batch data, or receive a customized quotation for your next project.
