Targeted Delivery Excellence: Cosperpharma’s GalNAc Series for Liver-Specific Therapeutics

Product List

Applications

Cosperpharma’s GalNAc series is essential for the development of advanced liver-targeted therapeutics:

siRNA Conjugates: Covalently attaching GalNAc to the sense or antisense strand of siRNA to facilitate receptor-mediated endocytosis into hepatocytes.

Antisense Oligonucleotides (ASOs): Enhancing the delivery and potency of ASOs targeting liver-expressed genes, such as those involved in metabolic disorders or viral infections.

Liver-Specific Delivery: Leveraging the high expression of ASGPR on hepatocytes to achieve tissue-specific accumulation and reduce systemic toxicity.

Research and Development: Utilizing GalNAc-pentanoic acid and GalNAc-pentaamide-C3 as versatile intermediates for the synthesis of various GalNAc-oligonucleotide conjugates.

About the Product

The GalNAc series from Cosperpharma includes both activated derivatives ready for conjugation and the fundamental sugar moiety. GalNAc-pentanoic acid and GalNAc-pentaamide-C3 are specifically designed as linker-ready GalNAc units, allowing for efficient coupling to oligonucleotides or other targeting moieties. The N-Acetyl-D-galactosamine serves as the core ligand, providing the specific recognition element for ASGPR. All products are synthesized under strictly controlled conditions and are rigorously purified to ensure high purity and consistent performance, making them ideal for both research and clinical development.

Contact Us

We are dedicated to supporting your targeted delivery strategies with the highest quality GalNAc derivatives. If you are interested in evaluating our GalNAc series for your next siRNA or ASO project, our technical team is ready to assist. Contact Cosperpharma today to discuss your specific conjugation requirements, request a detailed specification sheet, or receive a customized quotation.