O-Methylisourea Hemisulfate is an efficient guanidinating reagent used for the chemical conversion of lysine residues to homoarginine in proteins and peptides. The compound has been identified as the most effective guanidination reagent among commonly used agents, showing superior performance to S-methylisothiourea and 2-methyl-2-imidazoline at pH 10.5 and 65 °C . O-Methylisourea Hemisulfate is used in the synthesis of fluorouracil-class antineoplastic drugs, imidazole-class anthelmintic drugs, and novel herbicides . O-Methylisourea Hemisulfate is also used as a reagent for preparing (D,L)-arginine methyl ester analogues with antiarrhythmic activity and for synthesizing tetrahydropyrimidine derivatives with antibacterial activity against Mycobacterium tuberculosis, Staphylococcus aureus, and Bacillus subtilis .
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Product Name |
O-Methylisourea Hemisulfate |
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CAS Number |
52328-05-9 |
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Storage Condition |
Inert atmosphere, room temperature |
O-Methylisourea hemisulfate is used as a reagent for the preparation of (D,L)-arginine methyl ester analogs with antiarrhythmic activity. It is also used in the synthesis of ethyl [6-methyl-2-methoxy-3-(substituted phenylacetone)-4-(substituted phenyl)]-1,2,3,4-tetrahydropyrimidine-5-carboxylate with antibacterial activity, which has different concentration ranges against *Mycobacterium tuberculosis*, *Staphylococcus aureus* and *Bacillus subtilis*.
When your proteomics research or pharmaceutical synthesis program requires efficient guanidination reagents, Cosperpharm delivers O-Methylisourea Hemisulfate with the purity, documentation, and supply reliability that customers demand.
Superior guanidination efficiency. O-Methylisourea Hemisulfate has been identified as the most effective guanidination reagent among commonly used agents, showing superior performance to S-methylisothiourea at pH 10.5 and 65 °C . This translates to higher peptide detection sensitivity and sequence coverage in MALDI-TOF workflows.
Documentation that supports your work. Every shipment includes a Certificate of Analysis (COA) with batch‑specific purity data and characterization — structured for direct insertion into your quality documentation.
Flexible supply for research through production. Cosperpharm supplies O-Methylisourea Hemisulfate from gram quantities for laboratory research to larger batch sizes for pharmaceutical intermediate production.
Q1: What is the role of O-Methylisourea Hemisulfate in proteomics?
A: O-Methylisourea Hemisulfate is a guanidinating reagent used to convert lysine residues to homoarginine in proteins and peptides. This modification increases peptide basicity and improves ionization efficiency, enhancing peptide detection sensitivity and sequence coverage in mass spectrometry .
Q2: How does O-Methylisourea Hemisulfate compare to other guanidination reagents?
A: O-Methylisourea Hemisulfate has been identified as the most effective guanidination reagent among commonly used agents, including S-methylisothiourea and 2-methyl-2-imidazoline. At pH 10.5 and 65 °C, it demonstrates superior guanidination efficiency .
From proteomics research to pharmaceutical synthesis, Cosperpharm provides the high-quality guanidination reagents and intermediates you need. Contact us today to discuss your O-Methylisourea Hemisulfate requirements.
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