OF-C4-Deg-Lin

OF-C4-Deg-Lin is an advanced ionizable lipid extensively utilized in the generation of lipid nanoparticles (LNPs) for the targeted delivery of siRNA and mRNA. The unique molecular architecture of OF-C4-Deg-Lin—which integrates a piperazine‑2,5‑dione core with two branched amines, each featuring two linoleic esters—enables efficient encapsulation of nucleic acids and promotes enhanced cellular uptake. In preclinical LNP formulations, OF-C4-Deg-Lin has demonstrated preferential protein expression in the spleen with minimal translation in the liver when delivering mRNA encoding luciferase, highlighting its potential for extrahepatic targeting applications. As the ionizable lipid component of LNPs, OF-C4-Deg-Lin modulates endosomal escape in response to the acidic pH of the endosomal compartment, making it a versatile and powerful building block for next‑generation RNA therapeutics.

Product Parameters

Why Cosperpharm?

At Cosperpharm, we understand that the success of your LNP formulation begins with the quality of your ionizable lipid. We supply OF-C4-Deg-Lin with verified purity (≥95% by HPLC) and rigorous analytical characterization. Our small‑volume packaging options (5 mg, 10 mg, 25 mg, 50 mg) are ideal for early‑stage formulation screening and process development. For R&D groups requiring larger quantities, Cosperpharm offers bulk supply with full batch‑to‑batch consistency. Every shipment from Cosperpharm is accompanied by a comprehensive Certificate of Analysis (COA) and is supported by our expert technical team. Whether you are developing mRNA vaccines, siRNA therapeutics, or CRISPR gene‑editing components, Cosperpharm is your trusted partner for OF-C4-Deg-Lin.

Application Scenarios

1. mRNA Vaccine Development

OF-C4-Deg-Lin serves as the ionizable lipid component in LNP formulations for mRNA vaccines. Its four‑tailed architecture facilitates high encapsulation efficiency and promotes endosomal escape, leading to robust protein expression in target tissues.

2. siRNA Therapeutic Formulation

The symmetrical multi‑arm structure of OF-C4-Deg-Lin enables the formation of stable LNPs that protect siRNA from nuclease degradation and deliver the payload to the cytosol of target cells for RNA interference‑mediated gene silencing.

3. Extrahepatic Targeting Research

OF-C4-Deg-Lin has demonstrated preferential protein expression in the spleen when delivering mRNA in vivo, with minimal translation in the liver. This property makes it a valuable tool for developing LNP systems that target immune cells or splenic tissues.

4. CRISPR‑Cas9 Gene Editing Delivery

The high payload capacity of OF-C4-Deg-Lin‑based LNPs makes them suitable for the co‑encapsulation of Cas9 mRNA and single guide RNA (sgRNA), enabling genome editing in vivo.

5. Lipid Nanoparticle Formulation Optimization

Process chemists and formulation scientists use OF-C4-Deg-Lin as a reference ionizable lipid for optimizing LNP manufacturing processes, including microfluidic mixing parameters, lipid composition screening, and stability testing.

6. Ionizable Lipid Structure‑Activity Studies

Medicinal chemists employ OF-C4-Deg-Lin as a benchmark molecule in structure‑activity relationship (SAR) studies exploring the influence of linker length, tail saturation, and core rigidity on LNP performance and tropism.

Quality Assurance at Cosperpharm

Each batch undergoes:

● Gas chromatography (GC) – purity ≥97.0%

● Non‑aqueous titration – purity ≥97.0%

● Refractive index – confirmatory analysis

● ¹H NMR – structural verification

● Appearance – colorless to light yellow to light orange clear liquid

A comprehensive COA, MSDS (with full GHS information), and certificate of origin accompany every shipment.

Contact us

Have questions about incorporating OF-C4-Deg-Lin into your LNF formulation workflow? Our technical team at Cosperpharm is ready to assist — from solubility guidance to stability study support. Request a quote, request a Certificate of Analysis, or discuss custom packaging options by emailing us directly. We respond to all inquiries within 24 hours, and small‑volume samples ship within 5–7 business days.