Palmitic anhydride

Palmitic Anhydride is a versatile acylating agent and chemical intermediate in organic synthesis. Palmitic Anhydride is the anhydride form of palmitic acid and functions as a potent reagent for introducing palmitoyl (C16) functionality into target molecules. Palmitic Anhydride is the preferred acylating agent for the industrial synthesis of Paliperidone Palmitate via esterification of Paliperidone. Palmitic Anhydride is also used in the synthesis of water-soluble N-palmitoyl chitosan (PLCS) by coupling with swollen chitosan, and in the production of surfactants, emulsifiers, cosmetics, and pharmaceutical intermediates.

Product Parameters

---

Parameter	Specification
Product Name	Palmitic Anhydride
CAS Number	623-65-4
Molecular Formula	C₃₂H₆₂O₃
Molecular Weight	494.83 g/mol
Appearance	White to almost white powder/crystal
Melting Point	61–64°C
Boiling Point	547.77°C
Density	0.8388
Solubility	Almost transparent in toluene
Storage Condition	room temperature , Inert atmosphere

Application

---

Palmitic Anhydride is a saturated fatty acid found in many natural sources (such as animal fats and vegetable oils). It is often used as a reagent in organic synthesis to introduce the palmitoyl (hexadecanoyl) functional group into other organic molecules. In addition, Palmitic anhydride has been used in the production of surfactants, lubricants and plasticizers, as well as in the preparation of cosmetics and pharmaceuticals.

 

Product Advantages

---

Potent Acylating Agent for Pharmaceutical Synthesis. Palmitic Anhydride is a potent acylating agent that efficiently introduces palmitoyl (hexadecanoyl) functionality into target molecules. It is the preferred reagent for the industrial synthesis of Paliperidone Palmitate, the long-acting injectable prodrug for schizophrenia treatment.

 

High Purity and Batch-to-Batch Consistency. Cosperpharm supplies Palmitic Anhydride with ≥96.0% purity (GC), ensuring consistent acylation efficiency and minimizing the introduction of process-related impurities into pharmaceutical intermediates.

 

Versatile Synthetic Building Block. Palmitic Anhydride is used in the synthesis of water-soluble N-palmitoyl chitosan (PLCS), as well as in the production of surfactants, emulsifiers, cosmetics, lubricants, plasticizers, and pharmaceutical intermediates.

 

Stable Crystalline Solid for Convenient Handling. Palmitic Anhydride is a stable crystalline solid with a melting point of 62–65°C, making it convenient to weigh and handle under standard laboratory conditions. It is moisture-sensitive and should be stored under inert gas.

 

Key Intermediate for Long-Acting Antipsychotic Prodrugs. Palmitic Anhydride enables the synthesis of palmitate ester prodrugs, a strategy successfully employed in the development of long-acting injectable formulations for improved medication adherence in psychiatric disorders.

 

Product Quality Assurance

---

Cosperpharm has established a comprehensive quality assurance system for Palmitic Anhydride that meets the rigorous expectations of pharmaceutical intermediate manufacturing:

 

Thorough analytical characterization. Each batch undergoes multi-technique analytical release testing: GC purity (≥96.0%), melting point verification (62–65°C), appearance verification (white to almost white powder/crystal), and identity confirmation.

 

Full batch traceability with retention samples. From raw material procurement through synthesis, purification, and final packaging, every step is fully documented and traceable. Each batch receives a unique lot number with sufficient retention samples maintained in accordance with Cosperpharm quality procedures.

 

Documentation ready for regulatory submission. Every shipment includes a Certificate of Analysis (COA) with batch-specific purity and characterization data, a Material Safety Data Sheet (SDS), and customs documentation for international delivery. For customers preparing regulatory filings for Paliperidone Palmitate, Cosperpharm provides additional documentation upon request.

 

Customer-initiated quality audits. Qualified customers are welcome to audit Cosperpharm's manufacturing, quality control, and documentation facilities. Please contact our regulatory team to schedule an audit. ISO compliance documentation is available upon request.

 

Contact Us

---

Looking for a reliable source of Palmitic Anhydride for your Paliperidone Palmitate esterification or other acylating applications? Cosperpharm offers this essential intermediate with verified purity (≥96% by GC), batch‑to‑batch consistency, and comprehensive documentation. Our supply chain team ensures fast delivery for both small‑scale R&D samples and bulk production orders, with full customs support for international shipments.

 

To discuss your requirements, request a safety data sheet, or obtain a tailored quotation, simply reach out via our online contact form or send an email to our chemical intermediates division. We pride ourselves on transparent pricing, realistic lead times, and technical support from experienced process chemists. Let Cosperpharm be your preferred partner for Palmitic Anhydride and related fatty acid derivatives – contact us now and experience the difference.