Tris[2-(MethylaMino)ethyl]aMine

Tris[2-(MethylaMino)ethyl]aMine is a versatile research chemical and high-purity building block utilized extensively in coordination chemistry, catalysis, and dendrimer synthesis. The tripodal polyamine architecture of Tris[2-(MethylaMino)ethyl]aMine makes it an exceptional ligand for transition metals, forming stable complexes with copper(II) that serve as precatalysts for water oxidation reactions . In materials science, Tris[2-(MethylaMino)ethyl]aMine reacts rapidly with aromatic aldehydes to form polyimine networks, enabling the preparation of dynamic covalent organic frameworks and self-healing materials . Beyond its coordination applications, Tris[2-(MethylaMino)ethyl]aMine serves as a core moiety for constructing carbohydrate-based dendrimers, where its three secondary amine arms provide attachment points for dendritic wedges containing 21 to 27 monosaccharide residues—structures explored for drug delivery and biomaterial design . Supplied as a liquid with rigorously controlled purity, Tris[2-(MethylaMino)ethyl]aMine offers the reactivity and structural precision required for reproducible organometallic synthesis and supramolecular chemistry.

Product Parameters

Safety Information

Safety & Handling – What You Need to Know

This compound carries multiple hazard classifications:

Required Protective Measures:

● Eyes: Safety goggles (mandatory).

● Skin: Chemical-resistant gloves (nitrile). If you have a history of skin allergies, take extra precautions due to skin sensitizer classification.

● Respiratory: Use in a fume hood. Avoid breathing dust.

● First aid:

1. Eye contact – rinse with water for 15 min (S26).

2. Skin contact – wash with soap and water. If rash or irritation develops, seek medical advice (skin sensitizer).

3. Inhalation – move to fresh air.

● Storage: Keep container tightly sealed in a dry place at room temperature. Store away from ignition sources (combustible solid). Avoid contact with strong mineral acids (releases irritating free monoester).

● Disposal: Collect as chemical waste. WGK 1 indicates low water hazard, but best practice is not to flush down drains.

Synthetic Route

The synthesis of Tris[2-(MethylaMino)ethyl]aMine can be accomplished through multiple routes. One documented approach involves using tris(2-aminoethyl)amine as the starting material, which is first reacted with ethyl chloroformate in a biphasic water/toluene system to protect the primary amines as carbamates. Subsequent reduction with lithium aluminum hydride in tetrahydrofuran yields the target compound with approximately 80% yield . Alternatively, Tris[2-(MethylaMino)ethyl]aMine can be prepared through direct reaction of tris(2-aminoethyl)amine with methylamine under controlled conditions in methanol at elevated temperatures . Cosperpharm employs validated, scalable synthetic protocols with rigorous purification to ensure ≥97% purity and minimal tren contamination.