Z-D-Lys(Boc)-OH

Z-D-Lys(Boc)-OH is a pivotal building block widely utilized in peptide synthesis, allowing researchers to create specific peptide sequences with enhanced stability and bioactivity. Z-D-Lys(Boc)-OH is primarily employed in solid-phase peptide synthesis (SPPS), where the orthogonal protecting groups enable the selective protection and deprotection of the amino groups of lysine. Z-D-Lys(Boc)-OH also serves as a key intermediate in the synthesis of ligands, the exploration of protein-protein interactions, and the unraveling of metabolic pathways. The D-configuration of Z-D-Lys(Boc)-OH makes it particularly valuable for the synthesis of D-amino acid-containing peptides, which often exhibit enhanced resistance to enzymatic degradation compared to their L-counterparts.

Product Parameters

Product Advantages

Z-D-Lys(Boc)-OH features two orthogonal protecting groups: the Z group (hydrogenolysis-labile) protects the α-amino group, while the Boc group (acid-labile) protects the ε-amino group of the lysine side chain. This dual protection enables the selective deprotection and coupling of lysine at either amino position — a critical capability for synthesizing branched peptides, cyclic peptides, and peptides with site-specific modifications.

 Versatile Building Block for SPPS and Solution-Phase Synthesis

Z-D-Lys(Boc)-OH is suitable for both solid-phase peptide synthesis (SPPS) and solution-phase peptide synthesis. This versatility makes it a valuable reagent across multiple peptide synthesis platforms and applications.

 D-Configuration for Enhanced Peptide Stability

The D-configuration of Z-D-Lys(Boc)-OH enables the synthesis of D-amino acid-containing peptides. These peptides often exhibit enhanced resistance to enzymatic degradation compared to their L-counterparts, making them particularly valuable in the development of peptide-based therapeutics with improved pharmacokinetic properties.

 High-Purity Grade with Full Characterization

Z-D-Lys(Boc)-OH is supplied at ≥98% purity (HPLC) with comprehensive characterization including optical rotation. This ensures consistent performance in peptide coupling reactions and reliable results in downstream applications.

 Broad Utility in Medicinal Chemistry Research

Z-D-Lys(Boc)-OH has gained significant attention in medicinal chemistry for its potential therapeutic applications. It is widely utilized in synthesizing ligands, exploring protein-protein interactions, and unraveling metabolic pathways.

Storage Conditions

Store Z-D-Lys(Boc)-OH in a tightly sealed container at 2–8 °C. Keep the container dry and protected from light. The compound should be stored in a clean, well-ventilated area away from strong oxidizing agents, strong acids, and strong bases.

Shelf life: Please refer to the Certificate of Analysis for batch-specific shelf life information. Under recommended storage conditions, the compound is stable for extended periods.

Handling precautions: Use standard laboratory practices for handling fine powders and oils. Avoid generating dust. Wear appropriate personal protective equipment (lab coat, safety goggles, gloves). After handling, wash hands thoroughly. Refer to the Safety Data Sheet (SDS) for complete safety information.

Product Quality Assurance

Cosperpharm has established a comprehensive quality assurance system for Z-D-Lys(Boc)-OH that meets the rigorous expectations of peptide synthesis and pharmaceutical research applications:

Thorough analytical characterization. Each batch undergoes multi-technique analytical release testing: HPLC purity (≥98%), optical rotation verification ([α]²⁵/D = +8.6 ± 1°, c=1.98 in DMF), appearance verification, and identity confirmation.

Full batch traceability. From raw material procurement through protection, purification, and final packaging, every step is fully documented and traceable. Each batch receives a unique lot number with retention samples maintained in accordance with Cosperpharm quality procedures.

Stability monitoring program. Cosperpharm conducts ongoing stability studies under recommended storage conditions (0–8 °C). Stability summaries are available to support customer regulatory submissions.

Documentation ready for regulatory submission. Every shipment includes a Certificate of Analysis (COA) with batch-specific purity and characterization data, a Safety Data Sheet (SDS), and customs documentation. For customers developing peptide-based therapeutics, Cosperpharm provides comprehensive documentation packages upon request.

Customer-initiated quality audits. Qualified customers are welcome to audit Cosperpharm's manufacturing, quality control, and documentation facilities. Please contact our regulatory team to schedule an audit.

Contact Us

Looking for a reliable source of high-purity Z-D-Lys(Boc)-OH for your peptide synthesis project? Cosperpharm is here to help. Contact us today to discuss your requirements, request a quote, or inquire about our documentation packages.