Z-Trp(Boc)-OH.DCHA

Z-Trp(Boc)-OH.DCHA is a premium protected amino acid derivative designed for the synthesis of tryptophan-containing peptides where side-chain reactivity must be carefully controlled. The Z group in Z-Trp(Boc)-OH.DCHA protects the α-amino functionality and can be selectively removed by hydrogenolysis, while the Boc group safeguards the indole side chain and is cleaved under acidic conditions. The dicyclohexylammonium salt form of Z-Trp(Boc)-OH.DCHA provides enhanced crystallinity and stability compared to the free acid, making it easier to handle and store. As a doubly protected tryptophan building block, Z-Trp(Boc)-OH.DCHA enables the construction of complex peptide sequences without compromising the integrity of the tryptophan side chain.

 

Product Parameters

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Parameter	Specification
Product Name	Z-Trp(Boc)-OH.DCHA
CAS Number	218938-57-9
Molecular Formula	C₂₄H₂₆N₂O₆·C₁₂H₂₃N
Molecular Weight	619.79 g/mol
Physical Form	powder
Storage Temperature	Sealed in dry , Room Temperature

 

Why Cosperpharm?

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When your peptide synthesis requires protected tryptophan derivatives with verified purity and reliable supply, Cosperpharm delivers Z-Trp(Boc)-OH.DCHA with the quality assurance and technical support that demanding synthesis projects require.

 

Dual protection for challenging tryptophan chemistry. The indole side chain of tryptophan is notoriously reactive — prone to oxidation, alkylation, and other side reactions during peptide synthesis. Z-Trp(Boc)-OH.DCHA addresses this challenge with orthogonal Z and Boc protecting groups. Our analytical release protocol verifies both the integrity of the protecting groups and the absence of side-chain degradation products — because your complex peptide sequences depend on the quality of this building block.

 

Documentation that supports quality systems. Every shipment of Z-Trp(Boc)-OH.DCHA includes a Certificate of Analysis (COA) with batch-specific HPLC purity, optical rotation, and identity confirmation. Custom quality agreements, stability summaries, and additional documentation packages are available upon request for customers with stringent quality system requirements.

 

Flexible supply for every scale. Cosperpharm supplies Z-Trp(Boc)-OH.DCHA across the full range of applications — from gram-scale quantities for research and method development to multi-kilogram batches for process validation and commercial peptide manufacturing. R&D samples ship within 5–7 business days; bulk orders ship within 2–3 weeks.

 

Technical support from peptide chemistry experts. Our team has extensive experience with protected amino acid chemistry and can advise on deprotection strategies, coupling conditions, and compatibility with various peptide synthesis platforms. We understand the unique challenges of working with tryptophan-containing peptides and can help optimize your synthetic route.

 

Global reach with transparent pricing. Cosperpharm ships to pharmaceutical manufacturers, CROs, and research institutions worldwide, with full customs documentation included. Volume discounts apply at larger scales, and we communicate lead times upfront — no hidden fees, no unexpected delays.

 

FAQ

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Q1: What do the protecting groups Z and Boc stand for?

A: Z stands for carbobenzoxy (benzyloxycarbonyl) — a protecting group for the α-amino functionality that is removed by hydrogenolysis. Boc stands for tert-butyloxycarbonyl — a protecting group for the indole side chain nitrogen that is removed under acidic conditions. Together, they provide orthogonal protection for tryptophan residues during peptide synthesis.

 

Q2: Why is tryptophan side-chain protection necessary?

A: The indole side chain of tryptophan is highly reactive and prone to oxidation, alkylation, and other side reactions during peptide synthesis. The Boc group protects the indole nitrogen, preventing these unwanted reactions and preserving the integrity of the tryptophan residue.

 

Product Quality Assurance

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Cosperpharm has established a comprehensive quality assurance system for Z-Trp(Boc)-OH.DCHA that meets the rigorous expectations of peptide synthesis and pharmaceutical research applications:

 

Thorough analytical characterization. Each batch undergoes multi-technique analytical release testing: HPLC purity (≥98%), optical rotation confirmation (+23.0 ± 1°, c = 2 in MeOH), melting point verification (149–151 °C), appearance verification (solid), and identity confirmation.

 

Full batch traceability with retention samples. From raw material procurement through protection reactions, salt formation, purification, drying, and final packaging, every step is fully documented and traceable. Each batch receives a unique lot number with sufficient retention samples maintained in accordance with Cosperpharm quality procedures.

 

Stability monitoring program. Cosperpharm conducts ongoing stability studies under recommended storage conditions (2–8 °C). Stability summaries are available to support customer quality requirements.

 

Documentation ready for quality systems. Every shipment includes a Certificate of Analysis (COA) with batch-specific purity and characterization data, a Safety Data Sheet (SDS), and customs documentation for international delivery. Custom quality agreements and additional documentation packages are available upon request.

 

Customer-initiated quality audits. Qualified customers are welcome to audit Cosperpharm's manufacturing, quality control, and documentation facilities. Please contact our regulatory team to schedule an audit.

 

Contact Us

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Need Z-Trp(Boc)-OH.DCHA for your next peptide synthesis project? Cosperpharm delivers protected amino acids with the quality, documentation, and technical support that researchers and pharmaceutical manufacturers trust. Get in touch with our team — we're here to help you succeed.