1,4-bis(2-aminoethyl)piperazine

1,4-bis(2-aminoethyl)piperazine is a high-purity chemical intermediate and research reagent widely employed as a building block in medicinal chemistry, polymer science, and materials research. In drug discovery, 1,4-bis(2-aminoethyl)piperazine serves as a critical precursor, with its primary amine groups enabling facile conjugation to pharmacophores—a strategy employed in the synthesis of bis-thiazolone derivatives as CDC25 phosphatase inhibitors and bisnaphthalimides as DNA topoisomerase II inhibitors . Beyond pharmaceuticals, 1,4-bis(2-aminoethyl)piperazine functions as an effective amine cross-linker or chain extender in the production of epoxy curing agents and polyurea coatings, where its tetra-functionality creates high-density polymer networks. Supplied as a low-melting solid at ambient temperature with storage under inert gas, 1,4-bis(2-aminoethyl)piperazine offers the purity and stability essential for reproducible synthetic transformations across research and process development scales.

Product Parameters

Safety Information

Safety & Handling – What You Need to Know

This compound carries multiple hazard classifications:

Required Protective Measures:

● Eyes: Safety goggles (mandatory).

● Skin: Chemical-resistant gloves (nitrile). If you have a history of skin allergies, take extra precautions due to skin sensitizer classification.

● Respiratory: Use in a fume hood. Avoid breathing dust.

● First aid:

1. Eye contact – rinse with water for 15 min (S26).

2. Skin contact – wash with soap and water. If rash or irritation develops, seek medical advice (skin sensitizer).

3. Inhalation – move to fresh air.

● Storage: Keep container tightly sealed in a dry place at room temperature. Store away from ignition sources (combustible solid). Avoid contact with strong mineral acids (releases irritating free monoester).

● Disposal: Collect as chemical waste. WGK 1 indicates low water hazard, but best practice is not to flush down drains.

Synthetic Route

The industrial synthesis of 1,4-bis(2-aminoethyl)piperazine commonly proceeds via the alkylation of piperazine. A standard method involves reacting piperazine with ethylene oxide or ethylene dichloride under controlled temperature and pressure . Alternatively, the reaction of piperazine with aziridine or a protected 2-bromoethylamine equivalent can yield the desired bis-adduct. These processes typically target symmetrical N,N'-disubstitution and are followed by distillation or recrystallization to achieve high purity. Cosperpharm employs optimized, scalable routes with rigorous purification to ensure minimal contamination by mono-substituted byproducts or piperazine oligomers.

Contact Us

Your next breakthrough in anticancer research, polymer innovation, or materials chemistry can begin with a reliable source of 1,4-bis(2-aminoethyl)piperazine. Connect with Cosperpharm to explore how we can support your project with high-quality specialty amines.