2-Benzyloxy-3-tert-butoxycarbonylamino-propionicacid

2-Benzyloxy-3-tert-butoxycarbonylamino-propionic acid is a specialized synthetic amino acid building block widely used in peptide synthesis and medicinal chemistry. The compound features an orthogonal protection strategy—the β-amino group is protected by a Boc (tert-butoxycarbonyl) group, while the α-hydroxyl group is masked as a benzyl ether (benzyloxy). This dual-protected architecture makes 2-Benzyloxy-3-tert-butoxycarbonylamino-propionic acid fully compatible with Boc-based solid-phase peptide synthesis (Boc-SPPS) and avoids aspartimide side reactions that can plague Fmoc-based analogs. 2-Benzyloxy-3-tert-butoxycarbonylamino-propionic acid is supplied as a solid with ≥95% purity. Unlike the widely used α-amino acid analog Boc-Ser(Bzl)-OH, 2-Benzyloxy-3-tert-butoxycarbonylamino-propionic acid features the amino group at the β-position, conferring distinct conformational properties and enzymatic stability that directly impact downstream peptide performance.

Product Parameters

Why Cosperpharm? – Our Competitive Advantages

Quality Assurance at Cosperpharm

Each batch undergoes:

 Gas chromatography (GC) – purity ≥97.0%

 Non‑aqueous titration – purity ≥97.0%

 Refractive index – confirmatory analysis

 ¹H NMR – structural verification

 Appearance – colorless to light yellow to light orange clear liquid

A comprehensive COA, MSDS (with full GHS information), and certificate of origin accompany every shipment.

Product Advantages

2-Benzyloxy-3-tert-butoxycarbonylamino-propionic acid features an orthogonal protection strategy with the β-amino group protected by Boc and the α-hydroxyl group masked as a benzyl ether. This dual protection enables selective deprotection and functionalization during peptide synthesis.

β-Amino Acid Topology

Unlike the widely used α-amino acid analog Boc-Ser(Bzl)-OH, 2-Benzyloxy-3-tert-butoxycarbonylamino-propionic acid features the amino group at the β-position. This β-amino acid topology confers distinct conformational properties and enhanced enzymatic stability, making it valuable for designing proteolytically stable peptides and peptidomimetics.

 Compatible with Boc-SPPS

2-Benzyloxy-3-tert-butoxycarbonylamino-propionic acid is fully compatible with Boc-based solid-phase peptide synthesis (Boc-SPPS) and avoids aspartimide side reactions that can plague Fmoc-based analogs.

 Unique Isoserine Scaffold

Belonging to the isoserine family, 2-Benzyloxy-3-tert-butoxycarbonylamino-propionic acid provides a distinct three-dimensional geometry compared to standard amino acids, enabling the design of peptides and peptidomimetics with unique biological properties.

 High-Purity Research-Grade Material

Supplied with ≥95% purity, this compound meets the quality standards required for advanced peptide synthesis and medicinal chemistry applications.

Contact Us