3,4-Difluoro-2-methoxyphenylacetic acid

3,4-Difluoro-2-methoxyphenylacetic acid is a key synthetic intermediate and building block in pharmaceutical research and development, particularly valuable for the construction of drug candidates requiring enhanced metabolic stability and lipophilicity. As a fluorinated phenylacetic acid derivative, 3,4-Difluoro-2-methoxyphenylacetic acid enables medicinal chemists to introduce critical physicochemical properties into target molecules. In analytical development contexts, 3,4-Difluoro-2-methoxyphenylacetic acid serves as a reference standard for monitoring synthetic processes. The unique electronic profile of 3,4-Difluoro-2-methoxyphenylacetic acid makes it a valuable tool for structure-activity relationship (SAR) studies exploring the impact of aromatic substitution on biological activity.

Product Parameters

Application

3,4-Difluoro-2-methoxyphenylacetic acid is an important fluorinated phenylacetic acid derivative that can serve as a key intermediate in inhibiting overactive or overexpressed signal transduction pathways in cancer tissues.

Product Advantages

 Strategic Fluorination for Drug Optimization

3,4-Difluoro-2-methoxyphenylacetic acid provides a strategic fluorination pattern that enhances metabolic stability and lipophilicity — key considerations in modern drug design.

 Versatile Synthetic Building Block

3,4-Difluoro-2-methoxyphenylacetic acid offers multiple functional handles for chemical derivatization, enabling the synthesis of diverse compound libraries through amidation, esterification, and other common transformations.

 Electronic Property Tuning

The electron-withdrawing fluorine atoms at the 3- and 4-positions significantly alter the electronic properties of the aromatic ring, providing a distinct profile compared to non-fluorinated or singly fluorinated analogs.

 High-Purity Reference Standard

Cosperpharm supplies 3,4-Difluoro-2-methoxyphenylacetic acid at ≥97% purity with full characterization data, suitable for medicinal chemistry, process development, and analytical applications.

FAQ

Q1: How should this compound be stored?

A: Store 3,4-Difluoro-2-methoxyphenylacetic acid in a tightly sealed container at 2–8°C or –20°C, protected from light .

Q2: Is 3,4-Difluoro-2-methoxyphenylacetic acid hazardous?

A: 3,4-Difluoro-2-methoxyphenylacetic acid is classified with hazard statements H302 (Harmful if swallowed), H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation) .

Contact Us

Need 3,4-Difluoro-2-methoxyphenylacetic acid for your drug discovery program or synthetic chemistry project? Cosperpharm delivers with the quality, documentation, and supply reliability you require. Contact our team today — we respond within 2 business hours.