3,4-Difluoro-2-methoxyphenylacetic acid is a key synthetic intermediate and building block in pharmaceutical research and development, particularly valuable for the construction of drug candidates requiring enhanced metabolic stability and lipophilicity. As a fluorinated phenylacetic acid derivative, 3,4-Difluoro-2-methoxyphenylacetic acid enables medicinal chemists to introduce critical physicochemical properties into target molecules. In analytical development contexts, 3,4-Difluoro-2-methoxyphenylacetic acid serves as a reference standard for monitoring synthetic processes. The unique electronic profile of 3,4-Difluoro-2-methoxyphenylacetic acid makes it a valuable tool for structure-activity relationship (SAR) studies exploring the impact of aromatic substitution on biological activity.
|
Parameter |
Specification |
|
Product Name |
3,4-Difluoro-2-methoxyphenylacetic acid |
|
CAS Number |
1558274-26-2 |
|
Molecular Formula |
C₉H₈F₂O₃ |
|
Molecular Weight |
202.15 g/mol |
|
Appearance |
White powder |
|
Boiling Point |
286.5 ± 35.0 °C |
|
Density |
1.354 ± 0.06 g/cm3 |
|
Storage Condition |
2–8°C |
3,4-Difluoro-2-methoxyphenylacetic acid is an important fluorinated phenylacetic acid derivative that can serve as a key intermediate in inhibiting overactive or overexpressed signal transduction pathways in cancer tissues.
Strategic Fluorination for Drug Optimization
3,4-Difluoro-2-methoxyphenylacetic acid provides a strategic fluorination pattern that enhances metabolic stability and lipophilicity — key considerations in modern drug design.
Versatile Synthetic Building Block
3,4-Difluoro-2-methoxyphenylacetic acid offers multiple functional handles for chemical derivatization, enabling the synthesis of diverse compound libraries through amidation, esterification, and other common transformations.
Electronic Property Tuning
The electron-withdrawing fluorine atoms at the 3- and 4-positions significantly alter the electronic properties of the aromatic ring, providing a distinct profile compared to non-fluorinated or singly fluorinated analogs.
High-Purity Reference Standard
Cosperpharm supplies 3,4-Difluoro-2-methoxyphenylacetic acid at ≥97% purity with full characterization data, suitable for medicinal chemistry, process development, and analytical applications.
Q1: How should this compound be stored?
A: Store 3,4-Difluoro-2-methoxyphenylacetic acid in a tightly sealed container at 2–8°C or –20°C, protected from light .
Q2: Is 3,4-Difluoro-2-methoxyphenylacetic acid hazardous?
A: 3,4-Difluoro-2-methoxyphenylacetic acid is classified with hazard statements H302 (Harmful if swallowed), H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation) .
Need 3,4-Difluoro-2-methoxyphenylacetic acid for your drug discovery program or synthetic chemistry project? Cosperpharm delivers with the quality, documentation, and supply reliability you require. Contact our team today — we respond within 2 business hours.
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