4-Ethynylpyridine hydrochloride

4-Ethynylpyridine hydrochloride is a versatile specialty building block widely used in organic synthesis, coordination chemistry, and materials science. As a terminal alkyne‑substituted pyridine derivative, 4-Ethynylpyridine hydrochloride enables participation in Sonogashira couplings and copper‑catalyzed azide‑alkyne cycloaddition (CuAAC) reactions, while the pyridyl nitrogen acts as a coordination site for metal complexation. The para‑substitution geometry of 4-Ethynylpyridine hydrochloride is essential for applications requiring linear molecular architectures, including the synthesis of conjugated diynes, metal‑organic frameworks, and molecular wires. In medicinal chemistry, 4-Ethynylpyridine hydrochloride is used as a ligand for the synthesis of various metallic complexes and as a building block in drug discovery.

Product Parameters

FAQ

Q1: What chemical reactions can this compound undergo?

A: 4-Ethynylpyridine hydrochloride undergoes Sonogashira couplings, CuAAC click reactions, addition of hydrogen halides (forming geminal dihaloalkanes), hydroboration‑oxidation (converting terminal alkynes to aldehydes), hydrogenation (alkane formation), and Cadiot‑Chodkiewicz coupling (forming conjugated diynes).

Q2: How should this compound be stored?

A: Store 4-Ethynylpyridine hydrochloride in a tightly sealed container under inert atmosphere (nitrogen or argon) at 2–8 °C, protected from light and moisture. The compound is hygroscopic.

Storage Conditions

Store 4-Ethynylpyridine hydrochloride in a tightly sealed container under inert atmosphere (nitrogen or argon) at 2–8 °C for short‑term storage or at –20 °C for long‑term storage. Protect from light and keep the container dry. The compound is hygroscopic; therefore, desiccated storage is strongly recommended.

Shelf life: 12 months when stored at 2–8 °C in a sealed container under inert atmosphere.

Handling precautions: Use only in a fume hood. Wear chemical‑resistant gloves, safety goggles, and a lab coat. Avoid generating dust or aerosols. Do not eat, drink, or smoke in work areas. After handling, wash hands thoroughly. Refer to the Safety Data Sheet (SDS) for complete safety information.

Quality Assurance at Cosperpharm

Each batch undergoes:

● Gas chromatography (GC) – purity ≥97.0%

● Non‑aqueous titration – purity ≥97.0%

● Refractive index – confirmatory analysis

● ¹H NMR – structural verification

● Appearance – colorless to light yellow to light orange clear liquid

A comprehensive COA, MSDS (with full GHS information), and certificate of origin accompany every shipment.

Contact Us

Working with 4-Ethynylpyridine hydrochloride for MOF construction, cross‑coupling reactions, or ligand synthesis? Whatever your application, Cosperpharm is here to supply the high‑quality material you need — along with the technical support and reliable delivery your timeline demands. Contact us for a quote, lead time information, or to discuss your specific research needs.