5-Bromo-4-fluoro-1-methyl-1H-indazole

5-Bromo-4-fluoro-1-methyl-1H-indazole is a high-value pharmaceutical intermediate and building block widely employed in the synthesis of non-peptide glucagon-like peptide-1 (GLP-1) receptor agonists for the treatment of obesity and type 2 diabetes . The indazole scaffold of 5-Bromo-4-fluoro-1-methyl-1H-indazole provides a rigid, planar heterocyclic core that is ideal for constructing molecules with defined three-dimensional architectures for receptor binding. The bromine substituent on 5-Bromo-4-fluoro-1-methyl-1H-indazole serves as a critical functional handle for transition-metal-catalyzed cross-coupling reactions, including Suzuki, Buchwald-Hartwig, and Stille couplings, enabling the efficient elaboration of the indazole core into diverse compound libraries. The fluorine atom at the 4-position of 5-Bromo-4-fluoro-1-methyl-1H-indazole can significantly impact the pharmacological properties of derived compounds, including lipophilicity, metabolic stability, and binding affinity to biological targets . As a versatile synthetic intermediate, 5-Bromo-4-fluoro-1-methyl-1H-indazole is indispensable for medicinal chemistry programs targeting GLP-1 receptor modulation and other therapeutic areas.

Product Parameters

Why Cosperpharm?

When your GLP-1 agonist program or medicinal chemistry campaign requires a reliable halogenated indazole building block, Cosperpharm delivers 5-Bromo-4-fluoro-1-methyl-1H-indazole with the analytical rigor and supply flexibility that pharmaceutical researchers demand.

The bromine handle is your gateway to molecular diversity. The 5-bromo substituent on 5-Bromo-4-fluoro-1-methyl-1H-indazole is the critical functional handle for palladium-catalyzed cross-coupling reactions that elaborate this core into diverse compound libraries. Any impurity in this starting material will compromise the efficiency of your coupling reactions and the purity of your final products. Cosperpharm's analytical release protocol includes HPLC purity verification (≥95% to ≥99%) and identity confirmation to ensure your synthetic sequence starts from a clean foundation.

Documentation that supports your research. Every shipment includes a Certificate of Analysis (COA) with batch-specific purity data, chromatographic traceability, and physical characterization. Custom quality documentation and stability summaries are available upon request.

Flexible supply across all development stages. Cosperpharm supplies 5-Bromo-4-fluoro-1-methyl-1H-indazole from 100mg reference quantities for medicinal chemistry screening and method development, to gram-scale batches for process optimization, to bulk quantities for commercial manufacturing. R&D samples ship promptly; bulk orders are coordinated to meet your production timeline.

Technical support for cross-coupling chemistry. Our process chemistry team can advise on Suzuki-Miyaura, Buchwald-Hartwig, and other transition-metal-catalyzed coupling conditions for functionalizing the bromine handle, drawing on extensive experience with halogenated heterocyclic building blocks.

Global reach with transparent communication. Cosperpharm ships to pharmaceutical companies, CROs, and research institutions worldwide with full customs documentation. Volume discounts apply at larger scales, and we communicate lead times upfront.

FAQ

Q1: What is the primary pharmaceutical application?

A: 5-Bromo-4-fluoro-1-methyl-1H-indazole is a key intermediate in the synthesis of non-peptide GLP-1 receptor agonists for the treatment of obesity and type 2 diabetes . It is specifically used in the production of orforglipron, an oral GLP-1 agonist .

Q2: What is the role of the bromine substituent?

A: The 5-bromo substituent serves as a functional handle for palladium-catalyzed cross-coupling reactions (Suzuki, Buchwald-Hartwig, Stille), enabling efficient functionalization of the indazole core for structure-activity relationship studies .

Storage Conditions

Store 5-Bromo-4-fluoro-1-methyl-1H-indazole in a tightly sealed container, dry, at room temperature, protected from moisture and light . For long-term storage, storage at −20 °C (powder) is recommended . Keep the container in a well-ventilated place and away from sources of ignition and direct sunlight.

Handling precautions: Use only in a fume hood or well-ventilated area. Wear chemical-resistant gloves, safety goggles, and a lab coat. Avoid generating dust or aerosols. Do not eat, drink or smoke in work areas. After handling, wash hands thoroughly. Avoid release to the environment, as the compound is very toxic to aquatic life with long-lasting effects . Refer to the Safety Data Sheet (SDS) for complete safety information.

Contact Us

Securing 5-Bromo-4-fluoro-1-methyl-1H-indazole for your GLP-1 agonist program or medicinal chemistry campaign should be straightforward. Cosperpharm makes it simple—reach out today to discuss your requirements, request a quote, or schedule a technical consultation with our process chemistry team.