5-Chloro-3-methyl-1-benzofuran-2-carbaldehyde

5-Chloro-3-methyl-1-benzofuran-2-carbaldehyde (CAS 1131-07-3) is a heterocyclic aromatic aldehyde that belongs to the benzofuran family — a class of fused bicyclic heterocycles consisting of a benzene ring fused to a furan ring. The molecular formula is C₁₀H₇ClO₂ with a molecular weight of 194.61 g/mol, and the compound is typically supplied at ≥95% purity.

In medicinal chemistry, 5-chloro-3-methyl-1-benzofuran-2-carbaldehyde serves as a key intermediate for the synthesis of pharmaceutical candidates. The benzofuran core is a privileged scaffold in drug discovery, found in numerous bioactive molecules, and 5-chloro-3-methyl-1-benzofuran-2-carbaldehyde has been utilized in the construction of compounds targeting central nervous system disorders, viral infections, and inflammatory diseases. The aldehyde group enables diverse derivatization pathways, including condensation with primary amines to form Schiff bases and participation in Claisen‑Schmidt condensations for the synthesis of chalcone derivatives.

In antiviral research, 5-chloro-3-methyl-1-benzofuran-2-carbaldehyde is a valuable synthetic intermediate for preparing benzofuran derivatives that act as hepatitis C virus (HCV) NS5B polymerase inhibitors, a key target for treating chronic HCV infection. Furthermore, benzofuran derivatives related to 5-chloro-3-methyl-1-benzofuran-2-carbaldehyde have been shown to inhibit tumor necrosis factor‑α (TNF‑α) production and exhibit improved oral absorbability, making them candidates for anti‑inflammatory and immunomodulatory therapies. Other benzofuran derivatives demonstrate excellent action to inhibit neurodegeneration with low toxicity and good brain penetrability, suggesting potential applications in treating neurodegenerative diseases such as Alzheimer‘s and Parkinson’s disease.

In organic synthesis, 5-chloro-3-methyl-1-benzofuran-2-carbaldehyde serves as a versatile building block for constructing more complex heterocyclic systems. Research has demonstrated its utility in the synthesis of benzodiazepines and benzothiazepines bearing a benzofuran moiety as central nervous system depressants. Benzofuran‑3‑aryl derivatives, a class accessed from intermediates such as 5-chloro-3-methyl-1-benzofuran-2-carbaldehyde, are known to have various pharmacological effects including anticancer, antimicrobial, antibacterial, anti‑arrhythmic, and anti‑inflammatory effects.

Product Parameters

Why Cosperpharm? – Our Competitive Advantages

Storage Conditions

● Temperature: Sealed in dry, room temperature (15–25 °C); for long‑term storage (>12 months), store in a cool, dry place

● Container: Airtight, tightly sealed container

● Protection: Store away from moisture, light, strong oxidizing agents, and strong bases

● Desiccation: Keep in a dry environment; the aldehyde group may be sensitive to prolonged exposure to moisture

● Stability: Stable under recommended storage conditions for up to 24 months

● Incompatibilities: Strong oxidizing agents, strong bases, strong acids, amines (can form imines over time)

● DOT/IATA Transport: Not hazardous material under normal transport conditions

Handling recommendation: As a solid, the compound is easy to weigh and handle. Use in a fume hood and avoid generating dust. The aldehyde group may cause skin and eye irritation; wear appropriate PPE (gloves, goggles, lab coat). After opening, reseal the container tightly to exclude moisture and air, which may lead to oxidation or condensation side reactions. Safety data sheet (SDS) is available upon request.

Quality Assurance at Cosperpharm

Each batch undergoes:

● Gas chromatography (GC) – purity ≥97.0%

● Non‑aqueous titration – purity ≥97.0%

● Refractive index – confirmatory analysis

● ¹H NMR – structural verification

● Appearance – colorless to light yellow to light orange clear liquid

A comprehensive COA, MSDS (with full GHS information), and certificate of origin accompany every shipment.

Contact Us

Let’s discuss how Cosperpharm can support your next research or production project.Thank you for considering Cosperpharm as your trusted partner for 5-Chloro-3-methyl-1-benzofuran-2-carbaldehyde (CAS 1131-07-3). Our sales and technical support teams are ready to assist you with pricing, samples, documentation, or custom synthesis inquiries.