6-Cyano-2-naphthol is an aromatic alcohol and pharmaceutical intermediate with a distinctive naphthalene structure. 6-Cyano-2-naphthol serves as a key intermediate in the synthesis of nafamostat mesilate (Futhan), a serine protease inhibitor used clinically as an anticoagulant and for the treatment of pancreatitis. 6-Cyano-2-naphthol is also utilized in the preparation of various pharmaceutical compounds, including brominated and chlorinated derivatives for further functionalization. Additionally, 6-Cyano-2-naphthol has been extensively studied for its photophysical properties as a superphotoacid, making it valuable in both industrial organic synthesis and fundamental photochemical research.
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6-Cyano-2-naphthol |
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2–8°C; or -20°C freezer; sealed, dry |
6-Cyano-2-naphthol can be used as an organic synthesis intermediate and a pharmaceutical intermediate, mainly in the laboratory R&D process and chemical production process.
Q1: What is the primary pharmaceutical application of 6-Cyano-2-naphthol?
A: 6-Cyano-2-naphthol is the key intermediate in the synthesis of nafamostat mesilate (Futhan), a serine protease inhibitor used clinically as an anticoagulant, for the treatment of acute pancreatitis, and for disseminated intravascular coagulation (DIC).
Q2: What are the physical properties of this compound?
A: 6-Cyano-2-naphthol is a crystalline solid (brown to off-white) with a melting point of 165.5–170.5°C, molecular formula C₁₁H₇NO, and molecular weight 169.18 g/mol.
Store 6-Cyano-2-naphthol in a tightly sealed container at 2–8°C or –20°C freezer, protected from light and moisture. Keep away from strong oxidizing agents and strong bases. The compound is stable under recommended storage conditions. Allow the sealed container to reach ambient temperature before opening to minimize moisture condensation.
Shelf life: 2–3 years under recommended storage conditions. Stability data are available upon request.
Handling precautions: Use in a fume hood. Wear chemical-resistant gloves, safety goggles, and a lab coat. Avoid generating dust or aerosols. After handling, wash hands thoroughly. Refer to the Safety Data Sheet (SDS) for complete safety information.
Looking for a reliable source of 6-Cyano-2-naphthol for your nafamostat mesilate synthesis, photochemistry research, or pharmaceutical development program? Cosperpharm offers competitive pricing, global shipping, and responsive technical support. Contact us today for a quote or to discuss your project requirements.
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