Boc-D-Leu-OH.H2O

Boc-D-Leu-OH·H₂O is a specialized N-Boc-protected amino acid reagent designed for the incorporation of D-leucine into synthetic peptides and pharmaceutical intermediates. As a protected form of the unnatural D-enantiomer of leucine, Boc-D-Leu-OH·H₂O enables peptide chemists to introduce D-amino acids that confer resistance to proteolytic degradation and modulate receptor binding selectivity. The Boc protecting group on Boc-D-Leu-OH·H₂O provides orthogonal protection during solid-phase and solution-phase peptide synthesis, while the monohydrate crystalline form ensures excellent handling properties and long-term stability. Boc-D-Leu-OH·H₂O is widely employed in the synthesis of bioactive peptides, cyclic peptides, peptide-based drug candidates, and pharmaceutical intermediates where the D-leucine residue plays a critical role in biological activity and metabolic stability.

 

Product Parameters

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Parameter	Specification
Product Name	Boc-D-Leu-OH·H₂O
CAS Number	16937-99-8
Molecular Formula	C₁₁H₂₁NO₄
Molecular Weight	231.29 g/mol
Physical Form	Crystalline powder
Appearance	White powder
Melting Point	85–87°C
Boiling Point	356.0±25.0℃
Solubility	Soluble in common organic solvents; soluble in acetic acid
Storage Condition	Keep in dark place,Sealed in dry,Room Temperature
Density	1.061±0.06 g/cm3(Predicted)
pKa	4.02±0.21

 

Application

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With the continuous advancement of modern medicine, the clinical applications of the non-natural chiral amino acid BOC-D-leucine have expanded significantly. As a hydrophobic amino acid featuring a linear chain that occupies substantial molecular space, BOC-D-leucine effectively controls peptide molecular conformation during biosynthesis, enhances the molecular stability of peptides under enzymatic degradation, and preserves the functional value of the original protein. Consequently, it has found extensive applications in biology, chemistry, and pharmaceuticals as a nutritional fortifier, animal feed additive, synthetic pharmaceutical intermediate, and precursor for developing anti-AIDS drugs and hepatitis virus inhibitors.

 

Product Advantages

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Enantiopure D-Leucine for Metabolic Stability

Boc-D-Leu-OH·H₂O delivers the D-enantiomer of leucine in high optical purity, enabling the synthesis of peptides with enhanced resistance to proteolytic degradation. D-amino acid-containing peptides often exhibit improved metabolic stability and altered receptor binding profiles compared to their L-enantiomer counterparts.

 

 Boc Protection for Orthogonal Deprotection

The tert-butyloxycarbonyl (Boc) protecting group on Boc-D-Leu-OH·H₂O enables selective deprotection under mild acidic conditions (e.g., TFA), facilitating orthogonal protection strategies in complex peptide synthesis.

 

 Crystalline Monohydrate Form for Superior Handling

The monohydrate crystalline form of Boc-D-Leu-OH·H₂O provides excellent handling properties — the white powder is convenient to weigh, dispense, and store, with good stability under recommended storage conditions.

 

 Broad Utility in Bioactive Peptide Synthesis

Boc-D-Leu-OH·H₂O is employed in the synthesis of cyclic peptides, antimicrobial peptides, and peptide-based drug candidates where D-leucine contributes to biological activity, receptor selectivity, and metabolic stability.

 

 High Purity for Reliable Synthetic Outcomes

With ≥98% HPLC purity, Boc-D-Leu-OH·H₂O minimizes the introduction of impurities that could complicate peptide purification or compromise final product quality.

 

 Product Quality Assurance

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Cosperpharm has established a comprehensive quality assurance system for Boc-D-Leu-OH·H₂O that meets the rigorous expectations of peptide synthesis, pharmaceutical intermediate manufacturing, and research applications:

 

Thorough analytical characterization. Each batch undergoes multi-technique analytical release testing: HPLC purity verification (≥98%), optical rotation measurement ([α]²⁰/D = +24 ± 2°, c=2 in AcOH), appearance inspection (white powder), and melting point determination (80–90 °C).

 

Full batch traceability. From raw material procurement through synthesis, purification, crystallization, drying, and final packaging, every step is fully documented and traceable. Each batch receives a unique lot number with retention samples maintained in accordance with Cosperpharm quality procedures.

 

Documentation ready for your needs. Every shipment includes a Certificate of Analysis (COA) with batch-specific purity and characterization data, a Material Safety Data Sheet (SDS), and customs documentation for international delivery. Custom quality agreements, stability data, and additional documentation are available upon request.

 

Customer-initiated quality audits. Qualified customers are welcome to audit Cosperpharm‘s manufacturing, quality control, and documentation facilities. ISO compliance documentation is available upon request.

 

Contact Us

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Looking for Boc-D-Leu-OH·H₂O for your peptide synthesis or pharmaceutical research? Cosperpharm offers the quality, documentation, and supply flexibility you need. Get in touch with our team for pricing, availability, or technical support — we’re committed to helping you succeed.